Department of Geriatric Medicine, The Fourth Medical Center of PLA General Hospital, Beijing, China.
J Fluoresc. 2022 Mar;32(2):593-601. doi: 10.1007/s10895-021-02885-z. Epub 2022 Jan 11.
Via the solvothermal reaction between Zn(II) or Mn(II) salts and 5-(3,4-dicarboxylphenoxy)nicotinic acid (HL) ligand, a trifunctional N,O-building block having three diverse kinds of functional groups (O-ether, N-pyridyl and COOH), two new coordination polymers (CPs) could be generated, and their chemical formulae respectively are {[Mn(L)(HO)]·4HO} (1) and {[Zn(HL)]·NMP} (2). The complex 2 based on Zn(II) possesses high efficiency of fluorescence quenching for the nitrophenol (2,4,6-trinitrophenol, TNP; 4-nitrophenol, 4-NP; 3-nitrophenol, 3-NP; 2-nitrophenol, 2-NP) in the aqueous solution. Furthermore, the treatment activity of compounds on the atherosclerosis was assessed, and relevant mechanism was investigated. First of all, the ELISA assay was used to measure the content of the inflammatory cytokines released into the plasma. Besides, the levels of the NF-κb signaling pathway in the vascular endothelial cells were measured with real time RT-PCR. The hemolysis test was conducted in this research to measure the biocompatibility of the new compound.
通过 Zn(II)或 Mn(II)盐和 5-(3,4-二羧基苯氧基)烟酸 (HL)配体的溶剂热反应，可以生成具有三种不同官能团（O-醚、N-吡啶基和 COOH）的三功能 N,O-构建块，两种新的配位聚合物 (CP)，它们的化学式分别为{[Mn(L)(HO)]·4HO}（1）和{[Zn(HL)]·NMP}（2）。基于 Zn(II)的配合物 2 对水中的硝基苯酚（2,4,6-三硝基苯酚，TNP；4-硝基苯酚，4-NP；3-硝基苯酚，3-NP；2-硝基苯酚，2-NP）具有高效的荧光猝灭作用。此外，还评估了化合物对动脉粥样硬化的治疗活性，并研究了相关机制。首先，通过 ELISA 测定法测量释放到血浆中的炎症细胞因子的含量。此外，通过实时 RT-PCR 测量血管内皮细胞中 NF-κb 信号通路的水平。本研究进行了溶血试验以测量新化合物的生物相容性。
