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1
Hydrogen-bonded protons in the tertiary structure of yeast tRNAPhe in solution.溶液中酵母苯丙氨酸转运核糖核酸三级结构中的氢键质子。
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1561-4. doi: 10.1073/pnas.74.4.1561.
2
A study of secondary and tertiary solution structure of yeast tRNA(Asp) by nuclear magnetic resonance. Assignment of G.U ring NH and hydrogen-bonded base pair proton resonances.通过核磁共振研究酵母天冬氨酸转运核糖核酸（tRNA(Asp)）的二级和三级溶液结构。G.U环NH和氢键碱基对质子共振的归属。
Biochemistry. 1976 May 4;15(9):1883-8. doi: 10.1021/bi00654a014.
3
Identification of tertiary base pair resonances in the nuclear magnetic resonance spectra of transfer ribonucleic acid.在转移核糖核酸的核磁共振谱中鉴定三级碱基对共振
Biochemistry. 1979 Sep 4;18(18):3996-4005. doi: 10.1021/bi00585a024.
4
1H NMR studies of transfer RNA III: the observed and the computed spectra of the hydrogen-bonded NH resonances of baker's yeast transfer-RNA Phe.转运RNA的1H核磁共振研究III：面包酵母苯丙氨酸转运RNA氢键结合的NH共振的观测光谱与计算光谱
Nucleic Acids Res. 1977;4(5):1633-47. doi: 10.1093/nar/4.5.1633.
5
Nuclear magnetic resonance studies on yeast tRNAPhe. III. Assignments of the iminoproton resonances of the tertiary structure by means of nuclear Overhauser effect experiments at 500 MHz.酵母苯丙氨酸转运核糖核酸的核磁共振研究。III. 通过500兆赫的核Overhauser效应实验对三级结构亚氨基质子共振进行归属
Nucleic Acids Res. 1983 Jul 11;11(13):4501-20. doi: 10.1093/nar/11.13.4501.
6
Studies of yeast phenylalanine-accepting transfer ribonucleic acid backbone structure in solution by phosphorus-31 nuclear magnetic resonance spectroscopy.利用磷-31核磁共振光谱法对溶液中酵母苯丙氨酸接受转移核糖核酸主链结构进行的研究。
Biochemistry. 1979 Aug 7;18(16):3477-85. doi: 10.1021/bi00583a007.
7
A nuclear magnetic resonance study of secondary and tertiary structure in yeast tRNAPhe.酵母苯丙氨酸转运核糖核酸二级和三级结构的核磁共振研究。
Biochemistry. 1977 Nov 29;16(24):5261-73. doi: 10.1021/bi00643a016.
8
Proton nuclear magnetic resonance of minor nucleosides in yeast phenylalanine transfer ribonucleic acid. Conformational changes as a consequence of aminoacylation, removal of the Y base, and codon--anticodon interaction.酵母苯丙氨酸转移核糖核酸中稀有核苷的质子核磁共振。氨基酰化、Y碱基去除以及密码子-反密码子相互作用导致的构象变化。
Biochemistry. 1979 Jul 24;18(15):3189-99. doi: 10.1021/bi00582a001.
9
An NMR study of the exchange rates for protons involved in the secondary and tertiary structure of yeast tRNA Phe.酵母苯丙氨酸转运核糖核酸二级和三级结构中质子交换率的核磁共振研究。
Nucleic Acids Res. 1977 Oct;4(10):3599-615. doi: 10.1093/nar/4.10.3599.
10
Changes in tertiary structure accompanying a single base change in transfer RNA. Proton magnetic resonance and aminoacylation studies of Escherichia coli tRNAMet f1 and tRNAMet f3 and their spin-labeled (s4U8) derivatives.转运RNA中单个碱基变化所伴随的三级结构变化。大肠杆菌甲硫氨酸tRNAf1和甲硫氨酸tRNAf3及其自旋标记（s4U8）衍生物的质子磁共振和氨酰化研究。
Biochemistry. 1976 Sep 7;15(18):3917-24. doi: 10.1021/bi00663a003.

引用本文的文献

1
Demonstration of a tertiary interaction in solution between the extra arm and the D-stem in two different transfer RNA's by NMR.通过核磁共振证明两种不同转运核糖核酸（tRNA）中额外臂与D茎在溶液中的三级相互作用。
Nucleic Acids Res. 1977 Nov;4(11):3727-41. doi: 10.1093/nar/4.11.3727.

本文引用的文献

1
The Alkali Ion-DNA Interaction as Reflected in the Nuclear Relaxation Rates of Na and Rb.钠和铷的核弛豫速率所反映的碱金属离子与DNA的相互作用
Proc Natl Acad Sci U S A. 1975 Jan;72(1):245-7. doi: 10.1073/pnas.72.1.245.
2
Cooperative helix-coil transitions in half molecules of phenylalanine specific tRNA from yeast.来自酵母的苯丙氨酸特异性tRNA半分子中的协同螺旋-卷曲转变。
FEBS Lett. 1969 Sep;5(1):15-19. doi: 10.1016/0014-5793(69)80281-4.
3
Resolution of five conformational transitions in phenylalaninespecific tRNA from yeast.酵母苯丙氨酸特异性tRNA中五种构象转变的解析
FEBS Lett. 1970 Oct;10(5):352-357. doi: 10.1016/0014-5793(70)80471-9.
4
The structural geometry of co-ordinated base changes in transfer RNA.
J Mol Biol. 1974 Nov 5;89(3):511-6. doi: 10.1016/0022-2836(74)90480-x.
5
The general structure of transfer RNA molecules.转运RNA分子的一般结构。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4970-4. doi: 10.1073/pnas.71.12.4970.
6
NMR evidence for tertiary structure base pair in E. coli tRNA involving S4U8.
Nature. 1974 Dec 20;252(5485):738-9. doi: 10.1038/252738a0.
7
The molecular mechanism of thermal unfolding of Escherichia coli formylmethionine transfer RNA.大肠杆菌甲酰甲硫氨酸转移核糖核酸热解折叠的分子机制。
J Mol Biol. 1974 Jul 25;87(1):63-88. doi: 10.1016/0022-2836(74)90560-9.
8
Assignment of the hydrogen bonded proton resonances in (Escherichia coli) tRNAGlu by sequential melting.通过逐步解链对（大肠杆菌）tRNAGlu中氢键连接质子共振峰进行归属
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3239-42. doi: 10.1073/pnas.71.8.3239.
9
High resolution NMR study of the melting of yeast tRNA Phe.酵母苯丙氨酸转运核糖核酸（tRNA Phe）熔解的高分辨率核磁共振研究。
Biochem Biophys Res Commun. 1973 Dec 10;55(3):953-60. doi: 10.1016/0006-291x(73)91235-7.
10
The binding of ethidium bromide to different conformations of tRNA. Unfolding of tertiary structure.溴化乙锭与不同构象的转运核糖核酸（tRNA）的结合。三级结构的展开。
Eur J Biochem. 1973 Mar 15;33(3):511-6. doi: 10.1111/j.1432-1033.1973.tb02710.x.

溶液中酵母苯丙氨酸转运核糖核酸三级结构中的氢键质子。

Hydrogen-bonded protons in the tertiary structure of yeast tRNAPhe in solution.

作者信息

Römer R, Varadi V

出版信息

Proc Natl Acad Sci U S A. 1977 Apr;74(4):1561-4. doi: 10.1073/pnas.74.4.1561.

DOI:10.1073/pnas.74.4.1561
PMID:323858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430830/
Abstract

Temperature-dependent lowfield proton magnetic resonance spectra of yeast tRNAPhe were recorded between 10 and 15 parts per million. Seven resonances of hydrogen-bonded protons disappeared reversibly under two sets of conditions where the selective broadening of tertiary structure resonances were predicted by temperature jump experiments. The seven resonances were assigned to the seven tertiary hydrogen bonds expected between 10 and 15 parts per million from the crystal structure of yeast tRNAPhe. Some of the non-Watson-Crick base pairs have unusual unshifted standard chemical shifts after the ring current contributions calculated from the crystal coordinates were subtracted. The differences of the chemical shifts of homologous tertiary structure base pairs in Escherichia coli tRNAfMet and yeast tRNAPhe give experimental evidence for details of the conformational differences postulated by model building on the basis of the x-ray coordinates of yeast tRNAPhe and sequence homologies.

摘要

在百万分之10至15的范围内记录了酵母苯丙氨酸转运核糖核酸（tRNAPhe）的温度依赖性低场质子磁共振谱。在两组条件下，七个氢键质子的共振可逆消失，这两组条件下通过温度跃升实验预测了三级结构共振的选择性展宽。这七个共振被指定为酵母苯丙氨酸转运核糖核酸晶体结构中百万分之10至15之间预期的七个三级氢键。从晶体坐标计算出的环电流贡献被减去后，一些非沃森-克里克碱基对具有不寻常的未移动标准化学位移。大肠杆菌甲硫氨酸转运核糖核酸（tRNAfMet）和酵母苯丙氨酸转运核糖核酸中同源三级结构碱基对化学位移的差异，为基于酵母苯丙氨酸转运核糖核酸的x射线坐标和序列同源性通过模型构建推测的构象差异细节提供了实验证据。