[食物中毒患者血浆纤维连接蛋白水平的动态变化]

[Dynamics of the plasma fibronectin level in patients with food poisoning].

作者信息

Pak S G, Bogin I B, Kakhnovskaia N L, Sokurenko E V, Berchenko V V

出版信息

Ter Arkh. 1988;60(11):71-5.

Abstract

A study was made of the influence of the level and biological activity of plasma fibronectin of phagocytosis and opsonic activity of blood plasma in 147 patients with food toxinfections depending on a period and degree of severity of a course of disease. Plasma fibronectin concentration was determined by rocket immunoelectrophoresis. Fibronectin biological activity was assessed by cold heparin precipitation. Opsonic activity of blood plasma before and after fibronectin inactivation in it was investigated using indices of phagocytosis which was studied by optical microscopy. Food toxinfections were attended by a decrease in the level and biological activity of plasma fibronectin returning to normal during therapy and convalescence. A degree of the reduction of the level of plasma fibronectin reflected the severity of a course of food toxinfections. Phagocytic insufficiency developed in food toxinfections. One of its mechanisms was a decrease in opsonic activity of plasma fibronectin as a result of the reduction of its level.

摘要

对147例食物毒素感染患者血浆纤连蛋白水平和生物活性对血浆吞噬作用及调理活性的影响进行了研究，该研究依据疾病病程的时期和严重程度展开。血浆纤连蛋白浓度通过火箭免疫电泳法测定。纤连蛋白生物活性通过冷肝素沉淀法评估。利用光学显微镜研究吞噬作用指标，对血浆中纤连蛋白失活前后的血浆调理活性进行了研究。食物毒素感染伴有血浆纤连蛋白水平和生物活性降低，在治疗和康复期间恢复正常。血浆纤连蛋白水平降低的程度反映了食物毒素感染病程的严重程度。食物毒素感染中出现吞噬功能不全。其机制之一是血浆纤连蛋白水平降低导致其调理活性下降。