Department of Periodontology and Implant Dentistry, New York University, College of Dentistry, New York, New York, USA.
Department of Basic Sciences and Craniofacial Biology, New York University, College of Dentistry, New York, New York, USA.
Periodontol 2000. 2020 Jun;83(1):242-271. doi: 10.1111/prd.12327.
Approximately 47 million people worldwide have been diagnosed with dementia, 60%-80% of whom have dementia of the Alzheimer's disease type. Unfortunately, there is no cure in sight. Defining modifiable risk factors for Alzheimer's disease may have a significant impact on its prevalence. An increasing body of evidence suggests that chronic inflammation and microbial dysbiosis are risk factors for Alzheimer's disease. Periodontal disease is a chronic inflammatory disease that develops in response to response to microbial dysbiosis. Many studies have shown an association between periodontal disease and Alzheimer's disease. The intent of this paper was to review the existing literature and determine, using the Bradford Hill criteria, whether periodontal disease is causally related to Alzheimer's disease.
全球约有 4700 万人被诊断患有痴呆症，其中 60%-80%为阿尔茨海默病型痴呆症。遗憾的是，目前尚无治愈方法。确定阿尔茨海默病的可改变危险因素可能会对其患病率产生重大影响。越来越多的证据表明，慢性炎症和微生物失调是阿尔茨海默病的危险因素。牙周病是一种慢性炎症性疾病，是对微生物失调的反应。许多研究表明牙周病与阿尔茨海默病之间存在关联。本文的目的是回顾现有文献，并使用布拉德福德·希尔标准确定牙周病是否与阿尔茨海默病有因果关系。
