Zhao Miaomiao, Chang Haoxiang, Yue Yuxu, Zeng Xinyue, Wu Shaobang, Ren Xiuyun
Shanxi Medical University School and Hospital of Stomatology, Taiyuan, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
Front Med (Lausanne). 2025 Jan 21;12:1526406. doi: 10.3389/fmed.2025.1526406. eCollection 2025.
BACKGROUND: Periodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of the teeth triggered by bacterial infection and is recognized to promote systemic inflammation, leading to dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, gestational diabetes and preeclampsia, are linked to pregnancy complications. Recently, the correlation between periodontal disease and adverse pregnancy outcomes has garnered global attention. However, bibliometric studies in this area remain limited. This study aimed to visualize knowledge framework and research trends concerning the relationship between periodontal disease and adverse pregnancy outcomes from 2000 to 2023 through bibliometric approaches. METHODS: On September 22, 2024, articles and reviews on the connection between periodontal disease and adverse pregnancy outcomes were retrieved from the Web of Science Core Collection (WOSCC). CiteSpace [6.3.R1 (64-bit) Advanced] was used to perform knowledge mapping and bibliometric studies. RESULTS: Over the past 23 years, 932 articles from 73 countries were collected, with the U.S. contributing over one-third (355), followed by Brazil (85) and India (59). The literature in this field has experienced multiple growth phases since 2000, with particularly rapid growth observed after 2019. The University of North Carolina ( = 34, 3.65%) is the leading institution in terms of publication output, primarily representing the U.S. Notably, the and the are the most frequently cited journals in the fields of periodontology and obstetrics, respectively. These publications are authored by 94 researchers, with Steven Offenbacher being both the most productive and most highly cited author, making significant contributions to the field. A visual analysis of keywords identifies "oral microbiota," "oral health," "adverse pregnancy outcomes," and "global burden" as emerging research hotspots in exploring the correlation between periodontal disease and adverse pregnancy outcomes. CONCLUSIONS: This first bibliometric and visual analysis of periodontal disease and adverse pregnancy outcomes offers a concise overview of the field and suggests future research should focus on risk factors, high-risk populations, oral microbiota, mechanisms, interventions, and international collaboration.
背景：牙周病（PD）是一种由细菌感染引发的影响牙齿支持组织的慢性炎症性疾病，已知其会促进全身炎症反应，导致特定器官功能障碍。不良妊娠结局（APO），包括早产、小于胎龄儿、妊娠期糖尿病和先兆子痫，与妊娠并发症相关。近年来，牙周病与不良妊娠结局之间的相关性已引起全球关注。然而，该领域的文献计量学研究仍然有限。本研究旨在通过文献计量学方法，可视化2000年至2023年期间牙周病与不良妊娠结局之间关系的知识框架和研究趋势。 方法：2024年9月22日，从科学引文索引核心合集（WOSCC）中检索关于牙周病与不良妊娠结局之间联系的文章和综述。使用CiteSpace [6.3.R1（64位）高级版] 进行知识图谱绘制和文献计量学研究。 结果：在过去23年中，收集了来自73个国家的932篇文章，其中美国贡献超过三分之一（355篇），其次是巴西（85篇）和印度（59篇）。自2000年以来，该领域的文献经历了多个增长阶段，2019年后增长尤为迅速。北卡罗来纳大学（34篇，3.65%）是发表量领先的机构，主要代表美国。值得注意的是，《牙周病学杂志》和《产科学与妇科学》分别是牙周病学和产科学领域被引用最多的期刊。这些出版物由94位研究人员撰写，史蒂文·奥芬巴赫既是产量最高也是被引用最多的作者，为该领域做出了重大贡献。对关键词的可视化分析确定，“口腔微生物群”“口腔健康”“不良妊娠结局”和“全球负担”是探索牙周病与不良妊娠结局之间相关性的新兴研究热点。 结论：这项首次对牙周病与不良妊娠结局进行的文献计量学和可视化分析，简要概述了该领域，并表明未来的研究应关注危险因素、高危人群、口腔微生物群、机制、干预措施和国际合作。
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Cochrane Database Syst Rev. 2022-2-1
Int J Womens Health. 2025-7-2
Am J Obstet Gynecol. 2024-8
JAMA Intern Med. 2024-6-1
J Contemp Dent Pract. 2023-8-1
Periodontol 2000. 2024-10
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