Chernii Tatiana V
State Institution of Science «Research and Practical Center of Preventive and Clinical Medicine» State Administrative Department, Kyiv, Ukraine.
Wiad Lek. 2020;73(5):857-863.
The aim: A correction of cholinergic insufficiency for the treatment of cognitive impairment in chronic brain ischemia.
Materials and methods: In the period 2014 - 2017, 88 people aged 40 to 68 years were comprehensively examined in dynamics. Patients were divided into three groups, statistically comparable to the main disease - CCI 2 degrees, gender and age. In addition to the protocol, patients with discirculatory encephalopathy of all the investigated groups received a complex of drugs aimed at correcting neurotransmitter metabolism.
Results: The statistically significant manifestations of the recovery of cognitive function (according to the MMSE scale) after the application of the developed complex therapy were associated mainly with a decrease in impulsivity due to an increase in the level of attention. The statistically significant manifestations of a decrease in the level of anxietydepressive disorders (according to the DASS-21 scale) after the application of the developed complex therapy were associated mainly with a decrease in anxiety due to the restoration of neurohumoral balance.
Conclusions: The inclusion in the treatment protocol for CCI complex of drugs aimed at eliminating cholinergic deficiency, acetylcholinesterase inhibitors in combination with choline precursors, leads to the correction of cognitive impairment in chronic brain ischemia.
旨在纠正胆碱能功能不全以治疗慢性脑缺血中的认知障碍。
材料与方法：在2014年至2017年期间，对88名年龄在40至68岁之间的患者进行了动态综合检查。患者被分为三组，在主要疾病（2级慢性脑缺血）、性别和年龄方面具有统计学可比性。除了常规治疗方案外，所有研究组的循环性脑病患者均接受了旨在纠正神经递质代谢的药物组合治疗。
结果：应用所开发的综合疗法后，认知功能恢复（根据MMSE量表）的统计学显著表现主要与因注意力水平提高而导致的冲动性降低有关。应用所开发的综合疗法后，焦虑抑郁障碍水平降低（根据DASS - 21量表）的统计学显著表现主要与因神经体液平衡恢复而导致的焦虑降低有关。
结论：在慢性脑缺血的治疗方案中加入旨在消除胆碱能缺乏的药物组合，即乙酰胆碱酯酶抑制剂与胆碱前体联合使用，可纠正慢性脑缺血中的认知障碍。
