Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Bioorg Med Chem Lett. 2020 Jul 1;30(13):127201. doi: 10.1016/j.bmcl.2020.127201. Epub 2020 Apr 18.
A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effects against melanin synthesis and showed no toxicity in reconstituted human eye and skin tissues.
我们合成了一系列芳基硫醚衍生物，并评估了它们的抗黑色素生成活性。一些化合物，包括 3e、3i 和 3q，表现出良好的抗黑色素生成活性。在这些衍生物中，化合物 3i 对黑色素合成表现出良好的抑制作用，并且在重组人眼和皮肤组织中没有显示出毒性。
