Je Jun-Geon, Jiang Yunfei, Heo Jun-Ho, Li Xining, Jeon You-Jin, Ryu Bo-Mi
Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.
School of Food Engineering, Jilin Agriculture Science and Technology University, Jilin 132101, China.
Mar Drugs. 2022 Feb 4;20(2):123. doi: 10.3390/md20020123.
Melanin synthesis is a defense mechanism that prevents skin damage, but excessive accumulation of melanin occurs in the skin in various reactions such as pigmentation, lentigines, and freckles. Although anti-melanogenic effects have been demonstrated for various naturally occurring marine products that inhibit and control tyrosinase activity, most studies have not been extended to in vivo applications. Phlorofucofuroeckol-A (PFF-A, 12.5-100 µM) isolated from has previously been shown to have tyrosinase-mitigative effects in B16F10 cells, but it has not been evaluated in an in vivo model, and its underlying mechanism for anti-melanogenic effects has not been studied. In the present study, we evaluated the safety and efficacy of PFF-A for anti-melanogenic effects in an in vivo model. We selected low doses of PFF-A (1.5-15 nM) and investigated their mitigative effects on pigmentation stimulated by α-MSH in vivo and their related-mechanism in an in vitro model. The findings suggest that low-dose PFF-A derived from suppresses pigmentation in vivo and melanogenesis in vitro. Therefore, this study presents the possibility that PFF-A could be utilized as a new anti-melanogenic agent in the cosmeceutical industries.
黑色素合成是一种防止皮肤损伤的防御机制，但在色素沉着、雀斑样痣和雀斑等各种反应中，皮肤中会出现黑色素的过度积累。尽管多种天然海洋产物已被证明具有抑制和控制酪氨酸酶活性的抗黑色素生成作用，但大多数研究尚未扩展到体内应用。此前从[未提及具体来源]中分离出的叶褐素呋喃醚-A（PFF-A，12.5 - 100 µM）已被证明在B16F10细胞中具有减轻酪氨酸酶活性的作用，但尚未在体内模型中进行评估，其抗黑色素生成作用的潜在机制也未被研究。在本研究中，我们评估了PFF-A在体内模型中抗黑色素生成作用的安全性和有效性。我们选择了低剂量的PFF-A（1.5 - 15 nM），并研究了它们对体内α-MSH刺激的色素沉着的减轻作用及其在体外模型中的相关机制。研究结果表明，源自[未提及具体来源]的低剂量PFF-A可抑制体内色素沉着和体外黑色素生成。因此，本研究提出了PFF-A可作为化妆品行业新型抗黑色素生成剂的可能性。
