COVID-19：历史上有记录的首例冠状病毒大流行。

COVID-19: The first documented coronavirus pandemic in history.

机构信息

The Research Center for Emerging Viral Infection, Chang Gung University, Taoyuan, Taiwan.

The Research Center for Emerging Viral Infection, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

出版信息

Biomed J. 2020 Aug;43(4):328-333. doi: 10.1016/j.bj.2020.04.007. Epub 2020 May 5.

DOI:10.1016/j.bj.2020.04.007

PMID:32387617

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7199674/

Abstract

The novel human coronavirus disease COVID-19 has become the fifth documented pandemic since the 1918 flu pandemic. COVID-19 was first reported in Wuhan, China, and subsequently spread worldwide. The coronavirus was officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses based on phylogenetic analysis. SARS-CoV-2 is believed to be a spillover of an animal coronavirus and later adapted the ability of human-to-human transmission. Because the virus is highly contagious, it rapidly spreads and continuously evolves in the human population. In this review article, we discuss the basic properties, potential origin, and evolution of the novel human coronavirus. These factors may be critical for studies of pathogenicity, antiviral designs, and vaccine development against the virus.

摘要

新型人类冠状病毒疾病 COVID-19 已成为自 1918 年流感大流行以来第五次有记录的大流行。COVID-19 最初在中国武汉报告，随后在全球范围内传播。冠状病毒根据系统发育分析，被国际病毒分类委员会正式命名为严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）。据信，SARS-CoV-2 是一种动物冠状病毒的溢出物，后来适应了人与人之间传播的能力。由于该病毒具有高度传染性，因此在人类中迅速传播并不断进化。在这篇综述文章中，我们讨论了新型人类冠状病毒的基本特性、潜在起源和进化。这些因素对于研究该病毒的致病性、抗病毒设计和疫苗开发可能至关重要。