Cao A L, Lai Y W, Chen H G, Sheng L T, Pan A
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 May 6;54(5):555-562. doi: 10.3760/cma.j.cn112150-20190520-00407.
To systematically review research on the association between vitamin K and type 2 diabetes and diabetes-related biomarkers in humans, and evaluate the role of vitamin K in the prevention of type 2 diabetes. "Vitamin K", "type 2 diabetes" and related terms were searched in PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang Med Online up to November 2018. A total of 1 Chinese and 12 English articles were included. Among 6 observational studies, 5 of them showed that higher dietary vitamin K intake and plasma vitamin K level were associated with the decrease of the risk of type 2 diabetes. Among 6 clinical intervention studies, 5 of them indicated that the supplementation of vitamin K(1) or K2 could have positive influence on insulin metabolism. One Mendelian randomization study showed higher circulation vitamin K level might reduce the risk of type 2 diabetes. Vitamin K plays an important role in the prevention and control of type 2 diabetes, which may be related to the improvement of insulin metabolism and blood glucose level.
系统评价维生素K与人类2型糖尿病及糖尿病相关生物标志物之间关联的研究，并评估维生素K在预防2型糖尿病中的作用。截至2018年11月，在PubMed、EMBASE、中国知网（CNKI）和万方医学网中检索了“维生素K”“2型糖尿病”及相关术语。共纳入1篇中文文章和12篇英文文章。在6项观察性研究中，5项研究表明较高的膳食维生素K摄入量和血浆维生素K水平与2型糖尿病风险降低相关。在6项临床干预研究中，5项研究表明补充维生素K1或K2可能对胰岛素代谢有积极影响。1项孟德尔随机化研究表明较高的循环维生素K水平可能降低2型糖尿病风险。维生素K在2型糖尿病的预防和控制中起重要作用，这可能与胰岛素代谢和血糖水平的改善有关。
