Shahdadian Farnaz, Mohammadi Hamed, Rouhani Mohammad Hossein
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Horm Metab Res. 2018 Mar;50(3):227-235. doi: 10.1055/s-0044-100616. Epub 2018 Mar 9.
Type 2 diabetes mellitus (T2DM) is one of the most important public health issues. Vitamin K supplementation might have favorable effect on risk factors of T2DM. The aim of this study was to perform a systematic review and meta-analysis of interventional studies to examine the effect of vitamin K supplementation on glycemic indices. A systematic search was performed in electronic databases including PubMed, Science Direct, ProQuest, Institute of Scientific Information Web of Science, and Google scholar up to July 2017. We used a random effects model to estimate pooled effect size of fasting blood sugar (FBS), 2-h oral glucose tolerance test (2-h OGTT), fasting insulin (FINS), and homeostasis model assessment-estimated insulin resistance (HOMA-IR). Five clinical trials (533 participants) fulfilled the eligibility criteria of the present meta-analysis. Overall, meta-analysis could not show any beneficial effect of vitamin K supplementation on FBS (-0.91 mg/dl, 95% CI: -2.57, 0.76, p=0.28), FINS (-0.35 μIU/ml, 95% CI: -1.70, 1.00, p=0.61), HOMA-IR (-0.06, 95% CI: -0.32, -0.19, p=0.63), and 2-h OGTT (-4.00 mg/dl, 95% CI: -20.00, 11.99, p=0.62). Sensitivity analysis showed that overall estimates were not affected by elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, vitamin K supplementation had no significant effect on glycemic control in healthy subjects. However, further studies should be performed on diabetic and pre-diabetic patients to determine the effect of vitamin K supplementation on impaired glycemic control.
2型糖尿病（T2DM）是最重要的公共卫生问题之一。补充维生素K可能对T2DM的危险因素产生有利影响。本研究的目的是对干预性研究进行系统评价和荟萃分析，以检验补充维生素K对血糖指标的影响。截至2017年7月，我们在包括PubMed、Science Direct、ProQuest、科学信息研究所科学网和谷歌学术在内的电子数据库中进行了系统检索。我们使用随机效应模型来估计空腹血糖（FBS）、2小时口服葡萄糖耐量试验（2-h OGTT）、空腹胰岛素（FINS）和稳态模型评估估计的胰岛素抵抗（HOMA-IR）的合并效应量。五项临床试验（533名参与者）符合本荟萃分析的纳入标准。总体而言，荟萃分析未显示补充维生素K对FBS（-0.91mg/dl，95%CI：-2.57，0.76，p=0.28）、FINS（-0.35μIU/ml，95%CI：-1.70，1.00，p=0.61）、HOMA-IR（-0.06，95%CI：-0.32，0.19，p=0.63）和2-h OGTT（-4.00mg/dl，95%CI：-20.00，11.99，p=0.62）有任何有益影响。敏感性分析表明，总体估计不受任何一项研究剔除的影响。我们未观察到任何关于发表偏倚的证据。总之，补充维生素K对健康受试者的血糖控制没有显著影响。然而，应该对糖尿病患者和糖尿病前期患者进行进一步研究，以确定补充维生素K对血糖控制受损的影响。
