Institute for Molecular Medicine, Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.
Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA.
Can J Cardiol. 2020 May;36(5):683-693. doi: 10.1016/j.cjca.2020.02.095. Epub 2020 Mar 5.
It is common knowledge that the renin-angiotensin system (RAS), in particular angiotensin II acting through the angiotensin AT-receptor (ATR), is pivotal for the regulation of blood pressure (BP) and extracellular volume. More recent findings have revealed that the RAS is far more complex than initially thought and that it harbours additional mediators and receptors, which are able to counteract and thereby fine-tune ATR-mediated actions. This review will focus on the angiotensin AT-receptor (ATR), which is one of the "counter-regulatory" receptors within the RAS. It will review and discuss data related to the role of the ATR in regulation of BP and focus on the following 3 questions: Do peripheral ATR have an impact on BP regulation, and, if so, does this effect become apparent only under certain conditions? Are central nervous system ATR involved in regulation of BP, and, if so, which brain areas are involved and what are the mechanisms? Does dysfunction of ATR contribute to the pathogenesis of hypertension in preeclampsia?
众所周知，肾素-血管紧张素系统（RAS），特别是血管紧张素 II 通过血管紧张素 AT 受体（ATR）发挥作用，对血压（BP）和细胞外液容量的调节至关重要。最近的研究发现，RAS 远比最初想象的复杂，它还包含其他介质和受体，这些介质和受体能够对抗和微调 ATR 介导的作用。这篇综述将重点介绍血管紧张素 AT 受体（ATR），它是 RAS 中的“反向调节”受体之一。它将回顾和讨论与 ATR 在血压调节中的作用相关的数据，并重点关注以下 3 个问题：外周 ATR 是否对 BP 调节有影响，如果有，这种影响是否仅在某些条件下才明显？中枢神经系统 ATR 是否参与血压调节，如果是，涉及哪些脑区，其机制是什么？ATR 功能障碍是否导致子痫前期高血压的发病机制？
