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仅通过肛拭子检测到 SARS-CoV-2 轻度感染的婴儿:一例报告。

An infant with a mild SARS-CoV-2 infection detected only by anal swabs: a case report.

机构信息

Pidu District People's Hospital, Department of Infectious Diseases, Chengdu, Sichuan Province, China.

Pidu District People's Hospital, Department of Cardiology, Chengdu, Deyuan Chengdu, Sichuan Province, China.

出版信息

Braz J Infect Dis. 2020 May-Jun;24(3):247-249. doi: 10.1016/j.bjid.2020.04.009. Epub 2020 May 6.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and has spread rapidly worldwide. We present a mild SARS-CoV-2 infection in a baby with non-productive cough and normal chest computed tomography, in whom only anal swabs tested positive by real-time PCR testing for SARS-CoV-2. She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. Her anal swabs remained positive for eight days, whereas her throat swabs were persistently negative by real-time PCR testing. Mild and asymptomatic cases, especially in children, might present with PCR negative pharyngeal/nasal swabs and PCR positive anal swabs. Those patients are potential sources of infection via fecal-oral transmission for COVID-19.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)在中国武汉出现,并迅速在全球范围内传播。我们报告了一例婴儿轻度 SARS-CoV-2 感染,表现为无痰性咳嗽和正常的胸部计算机断层扫描,仅通过实时 PCR 检测分析肛拭子对 SARS-CoV-2 呈阳性。该婴儿接受了重组人干扰素 alfa-1b 雾化吸入治疗 10 天。她的肛拭子持续阳性 8 天,而实时 PCR 检测咽拭子和鼻拭子一直为阴性。轻症和无症状病例,尤其是儿童,可能出现咽/鼻拭子 PCR 阴性而肛拭子 PCR 阳性的情况。这些患者可能通过粪-口途径传播 COVID-19 而成为潜在的感染源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b61/9392028/8f82b1a9390e/gr1.jpg

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