Department of Conservative Dentistry and Periodontology, University Hospital Regensburg, Regensburg, Germany.
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
J Clin Periodontol. 2020 Jul;47(7):863-874. doi: 10.1111/jcpe.13302. Epub 2020 May 21.
To investigate tooth survival and clinical long-term outcomes up to 26 years following guided tissue regeneration (GTR) therapy in deep intra-bony defects.
Patients from three prospective clinical split-mouth studies, which investigated the outcomes of GTR therapy, were re-evaluated 21-26 years after surgery independent of the membrane type used, and tooth survival was assessed according to several site-specific and patient-related factors.
About 50 patients contributing 102 defects were available for this long-term follow-up. After up to 26 years (median 23.3 years), 52.9% of the teeth were still in situ. The median survival of the extracted teeth was 13.8 years. Patients with diabetes mellitus and/or smoking history lost significantly more teeth in the long term. Compared to the 1-year situation, there was no new median CAL loss after up to 26 years in the teeth which were still in situ.
Within the limitations of this study, our data show that more than 50% of the initially seriously diseased teeth were still in situ up to 26 years following GTR therapy despite an overall limited adherence to SPT. In the majority of these teeth, the CAL gain 1 year after GTR could be maintained over this long period.
研究引导组织再生（GTR）治疗深骨内缺损后长达 26 年的牙齿存活率和临床长期疗效。
对来自三项前瞻性临床分牙研究的患者进行了再评估，这些研究调查了 GTR 治疗的结果，在手术后 21-26 年进行了独立于使用的膜类型的评估，并根据几个特定于部位和患者相关的因素评估了牙齿存活率。
大约 50 名患者（共 102 个缺损）参与了这项长期随访。在长达 26 年（中位数 23.3 年）的随访后，52.9%的牙齿仍在原位。已拔除牙齿的中位生存时间为 13.8 年。患有糖尿病和/或吸烟史的患者在长期内失牙明显更多。与 1 年时的情况相比，在原位的牙齿在长达 26 年的时间内没有新的中位 CAL 丧失。
在本研究的限制范围内，我们的数据表明，尽管总体上对 SPT 的依从性有限，但在 GTR 治疗后长达 26 年的时间内，最初患有严重疾病的牙齿中仍有超过 50%的牙齿仍在原位。在这些牙齿中，大多数在 GTR 后 1 年获得的 CAL 增益可以在这段长时间内维持。
