Petsos Hari, Koronna Ilona, Ramich Tatjana, Nickles Katrin, Dannewitz Bettina, Schacher Beate, Eickholz Peter
Department of Periodontology, Center of Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Private Practice, Westenhellweg 10, 59494 Soest, Germany.
J Clin Med. 2022 Jan 21;11(3):543. doi: 10.3390/jcm11030543.
A similar long-term stable clinical attachment level (CAL) of infrabony defects (IBDs) after regenerative treatment compared to control teeth would indicate a high level of stability resulting from the regenerative approach.
Patients with a regeneratively treated IBD were screened 120 ± 12 months postoperatively for eligibility for study participation, and were included if complete baseline and 12-month examinations (plaque (PlI), periodontal probing depth (PPD), CAL) were available and a respective control tooth could be identified. Re-examination included clinical examination (PPD, CAL, PlI/GI, bleeding on probing, plaque control record, gingival bleeding index).
A total of 27 patients (16 females; age (median; lower/upper quartile): 57.0; 44.0/60.0 years; 6 smokers) contributed 27 IBDs (test), for each of which a control tooth was identified. Five test teeth (18.5%) were lost between 12 and 120 months. The remaining 22 test teeth revealed a significant CAL gain after 1 (2.5 mm; 1.0/4.0 mm, < 0.0001) and 10 (2.5 mm; 0.5/3.5 mm, < 0.0001) years, whereas control teeth were stable (1 year: 0.0 mm; 0.0/1.0 mm, = 0.396; 10 years: 0.0 mm; -1.0/1.5 mm, = 0.215). The study did not detect any significant CAL change between 1 and 10 years for test (-0.5 mm; -1.0/0.5 mm, = 0.414) and control teeth (0.0 mm; -1.0/1.0 mm, = 0.739). In 15 patients, test and control teeth revealed stable CAL values between 12 and 120 months.
Regenerative treatment of IBDs exhibited stability comparable to non-surgically treated, periodontally reduced sites over a 10-year period.
与对照牙相比，再生治疗后骨下袋缺损（IBD）的临床附着水平（CAL）长期稳定，这表明再生治疗方法具有较高的稳定性。
对接受再生治疗的IBD患者在术后120±12个月进行筛查，以确定其是否符合研究参与条件。如果有完整的基线和12个月检查（菌斑（PlI）、牙周探诊深度（PPD）、CAL），并且能够识别出相应的对照牙，则将患者纳入研究。复查包括临床检查（PPD、CAL、PlI/GI、探诊出血、菌斑控制记录、牙龈出血指数）。
共有27例患者（16例女性；年龄（中位数；下/上四分位数）：57.0；44.0/60.0岁；6例吸烟者）提供了27个IBD（试验组），每个IBD均识别出一颗对照牙。5颗试验牙（18.5%）在12至120个月之间脱落。其余22颗试验牙在1年（2.5mm；1.0/4.0mm，P<0.0001）和10年（2.5mm；0.5/3.5mm，P<0.0001）后CAL有显著增加，而对照牙则保持稳定（1年：0.0mm；0.0/1.0mm，P=0.396；10年：0.0mm；-1.0/1.5mm，P=0.215）。该研究未检测到试验牙（-0.5mm；-1.0/0.5mm，P=0.414）和对照牙（0.0mm；-1.0/1.0mm，P=0.739）在1至10年之间CAL有任何显著变化。15例患者的试验牙和对照牙在12至120个月之间CAL值保持稳定。
IBD的再生治疗在10年期间表现出与非手术治疗的牙周退缩部位相当的稳定性。
