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在实验条件下单独或联合应用时，[某种物质]与猪圆环病毒2型商业疫苗效果的比较。 （注：原文中“Comparison of and”这里有信息缺失，推测是比较某物质和猪圆环病毒2型商业疫苗，但具体物质不明）

Comparison of and porcine circovirus 2 commercial vaccines efficacy when applied separate or combined under experimental conditions.

作者信息

Sibila M, Guevara G, Cuadrado R, Pleguezuelos P, Pérez D, Pérez de Rozas A, Huerta E, Llorens A, Valero O, Pérez M, López C, Krejci R, Segalés J

机构信息

1IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA- UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

OIE Collaborating Centre for the Research and Control of Emerging and Re-emerging Swine Diseases in Europe (IRTA-CReSA), Bellaterra, Barcelona, Spain.

出版信息

Porcine Health Manag. 2020 May 4;6:11. doi: 10.1186/s40813-020-00148-0. eCollection 2020.

DOI:10.1186/s40813-020-00148-0
PMID:32391165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7197127/
Abstract

BACKGROUND

(Mhyo) and (PCV-2) are two of the most significant infectious agents causing economic losses in the weaning to slaughter period. Due to their similar vaccination age, the objective of this study was to assess the efficacy of two already existing Mhyo (Hyogen®) and PCV-2 (Circovac®) vaccines when administered separately or combined (RTM) by means of Mhyo or PCV-2 experimental challenges.

RESULTS

Seven groups of animals were included in the study, being three of them challenged with PCV-2, three with Mhyo and one composed of non-challenged, non-vaccinated pigs. Within each experimental challenge, non-vaccinated (NV) groups were compared with double vaccinated groups using the commercial products separated (VS) or combined (VC). Both vaccinated groups showed significant differences for most parameters measured regarding PCV-2 (serology, percentage of infected animals and viral load in tissues) and Mhyo (serology and gross lesions) when compared to NV groups. VS and VC offered similar results, being only significantly different the PCV-2 antibody values at different time points (higher in the VS group) of the study, although not at the termination day (21 days post-PCV-2 inoculation).

CONCLUSION

The present study expands the knowledge on the possibility of using two separate Mhyo and PCV-2 commercial vaccines as a RTM product, which offered equivalent virological, immunological and pathological outcomes as compared to these vaccines when used by separate.

摘要

背景

猪支原体肺炎（Mhyo）和猪圆环病毒2型（PCV - 2）是导致断奶至屠宰期经济损失的两种最重要的感染因子。由于它们的疫苗接种年龄相似，本研究的目的是通过Mhyo或PCV - 2实验性攻毒来评估两种现有Mhyo疫苗（Hyogen®）和PCV - 2疫苗（Circovac®）单独接种或联合接种（RTM）时的效果。

结果

本研究纳入了七组动物，其中三组用PCV - 2攻毒，三组用Mhyo攻毒，一组由未攻毒、未接种疫苗的猪组成。在每个实验性攻毒中，将未接种疫苗（NV）组与使用分开（VS）或联合（VC）的商业产品进行双重接种的组进行比较。与NV组相比，两个接种组在大多数关于PCV - 2（血清学、感染动物百分比和组织中的病毒载量）和Mhyo（血清学和肉眼病变）的测量参数上均显示出显著差异。VS和VC提供了相似的结果，在研究的不同时间点（VS组中较高）PCV - 2抗体值仅存在显著差异，尽管在接种PCV - 2后21天的终止日没有差异。

结论

本研究扩展了关于将两种单独的Mhyo和PCV - 2商业疫苗用作RTM产品可能性的知识，与单独使用这些疫苗相比，RTM产品在病毒学、免疫学和病理学结果方面相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/01b7b73284f5/40813_2020_148_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/8c31b6db430b/40813_2020_148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/78c408127ae2/40813_2020_148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/b25e6ce00c4d/40813_2020_148_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/9e7e5d6c0f75/40813_2020_148_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/01b7b73284f5/40813_2020_148_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/8c31b6db430b/40813_2020_148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/78c408127ae2/40813_2020_148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/b25e6ce00c4d/40813_2020_148_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/9e7e5d6c0f75/40813_2020_148_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da23/7197127/01b7b73284f5/40813_2020_148_Fig5_HTML.jpg

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本文引用的文献

1
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Vet Microbiol. 2018 Jun;219:23-29. doi: 10.1016/j.vetmic.2018.04.005. Epub 2018 Apr 4.
2
Factors associated with the growing-finishing performances of swine herds: an exploratory study on serological and herd level indicators.与猪群生长育肥性能相关的因素：一项关于血清学和猪群水平指标的探索性研究
Porcine Health Manag. 2018 Mar 22;4:6. doi: 10.1186/s40813-018-0082-9. eCollection 2018.
3
A field efficacy and safety trial in the Netherlands in pigs vaccinated at 3 weeks of age with a ready-to-use porcine circovirus type 2 and combined vaccine.
基于硫酸化壳聚糖多抗原微囊化的新型抗猪圆环病毒2型（PCV2）疫苗原型的设计
Vaccines (Basel). 2024 May 17;12(5):550. doi: 10.3390/vaccines12050550.
4
Efficacy Studies against PCV-2 of a New Trivalent Vaccine including PCV-2a and PCV-2b Genotypes and When Administered at 3 Weeks of Age.一种包含PCV-2a和PCV-2b基因型的新型三价疫苗在3周龄时接种对PCV-2的效力研究。
Vaccines (Basel). 2022 Dec 9;10(12):2108. doi: 10.3390/vaccines10122108.
5
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Vaccines (Basel). 2022 Aug 1;10(8):1234. doi: 10.3390/vaccines10081234.
6
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6
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