Chae Chanhee
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
Vet J. 2016 Jun;212:1-6. doi: 10.1016/j.tvjl.2015.10.030. Epub 2015 Oct 23.
Porcine respiratory disease is a multifactorial and complex disease caused by a combination of infectious pathogens, environmental stressors, differences in production systems, and various management practices; hence the name porcine respiratory disease complex (PRDC) is used. Porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and Mycoplasma hyopneumoniae are considered to be the most important pathogens that cause PRDC. Although interactions among the three major respiratory pathogens are well documented, it is also necessary to understand the interaction between vaccines and the three major respiratory pathogens. PRRSV and M. hyopneumoniae are well known to potentiate PCV2-associated lesions; however, PRRSV and mycoplasmal vaccines can both enhance PCV2 viraemia regardless of the effects of the actual PRRSV or M. hyopneumoniae infection. On the other hand, M. hyopneumoniae potentiates the severity of pneumonia induced by PRRSV, and vaccination against M. hyopneumoniae alone is also able to decrease PRRSV viraemia and PRRSV-induced lung lesions in dually infected pigs. This review focuses on (1) interactions between PCV2, PRRSV, and M. hyopneumoniae; and (2) interactions between vaccines and the three major respiratory pathogens.
猪呼吸道疾病是一种多因素的复杂疾病，由传染性病原体、环境应激源、生产系统差异以及各种管理措施共同引起；因此使用了猪呼吸道疾病综合征（PRDC）这一名称。猪圆环病毒2型（PCV2）、猪繁殖与呼吸综合征病毒（PRRSV）和猪肺炎支原体被认为是导致PRDC的最重要病原体。虽然这三种主要呼吸道病原体之间的相互作用已有充分记录，但了解疫苗与这三种主要呼吸道病原体之间的相互作用也很有必要。众所周知，PRRSV和猪肺炎支原体可增强与PCV2相关的病变；然而，无论实际的PRRSV或猪肺炎支原体感染情况如何，PRRSV疫苗和支原体疫苗都能增强PCV2病毒血症。另一方面，猪肺炎支原体可加重PRRSV诱导的肺炎严重程度，单独接种猪肺炎支原体疫苗也能够降低双重感染猪的PRRSV病毒血症和PRRSV诱导的肺部病变。本综述重点关注（1）PCV2、PRRSV和猪肺炎支原体之间的相互作用；以及（2）疫苗与三种主要呼吸道病原体之间的相互作用。
