Axin2子宫内膜干细胞：子宫内膜再生与癌症的根源
Axin2 endometrial stem cells: the source of endometrial regeneration and cancer.
作者信息
Syed Shafiq M, Tanwar Pradeep S
机构信息
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.
出版信息
Mol Cell Oncol. 2020 Mar 5;7(3):1729681. doi: 10.1080/23723556.2020.1729681. eCollection 2020.
Abstract
Menstruation is one of the basic but poorly understood life processes in primates during which females shed inner uterine lining every month only to be completely regenerated back within a week. The definitive evidence for the existence and/or identity of stem cells responsible for this process has remained elusive for more than six decades now. Recently, we reported Axin2, a classical Wnt reporter gene, as a marker for endometrial stem cells that also serve as the cells of origin for endometrial cancer.
摘要
月经是灵长类动物基本但却了解甚少的生命过程之一，在此过程中，雌性每月都会脱落子宫内膜内层，但一周内又会完全再生。六十多年来，负责这一过程的干细胞的存在和/或身份的确切证据一直难以捉摸。最近，我们报道了一种经典的Wnt报告基因Axin2，它可作为子宫内膜干细胞的标志物，而这些干细胞也是子宫内膜癌的起源细胞。
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本文引用的文献
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