Liu Hui, Wang Xiaojun, Shi Qiaoyun, Li Liuren, Zhang Qinghua, Wu Zhen-Long, Huang Xiao-Jun, Zhang Qing-Wen, Ye Wen-Cai, Wang Ying, Shi Lei
Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University, Guangzhou 510632, People's Republic of China.
ACS Omega. 2020 Apr 22;5(17):10167-10175. doi: 10.1021/acsomega.0c01019. eCollection 2020 May 5.
Two novel dimeric diarylheptanoids, alpinidinoids A [(±)-] and B (), with two unusual coupling patterns, together with a new naturally occurring diarylheptanoid dimer possessing a rare pyridine ring linkage (alpinidinoid C, ), were isolated from the rhizomes of . Their structures including absolute configurations were determined by extensive spectroscopic methods and theoretical calculations. All isolates were examined for their neuroprotective activities against oxygen-glucose deprivation and reoxygenation (OGD/R) damage in primary cortical neurons. Remarkably, the dextrorotatory enantiomer of alpinidinoid A [(+)-] significantly ameliorated OGD/R-induced neuronal apoptosis, which was dependent on the activation of the AKT/mTOR signaling pathway.
从[植物名称]的根茎中分离出两种具有两种不寻常偶联模式的新型二聚二芳基庚烷类化合物，高山黄芩素A[（±）-]和B（），以及一种具有罕见吡啶环连接的新天然二芳基庚烷类二聚体（高山黄芩素C，）。通过广泛的光谱方法和理论计算确定了它们的结构，包括绝对构型。检测了所有分离物对原代皮质神经元氧糖剥夺和复氧（OGD/R）损伤的神经保护活性。值得注意的是，高山黄芩素A的右旋对映体[（+）-]显著改善了OGD/R诱导的神经元凋亡，这依赖于AKT/mTOR信号通路的激活。
