School of Pharmacy, Monash University Malaysia, Malaysia; Tropical Medicine and Biology Platform, Monash University Malaysia, Malaysia.
School of Pharmacy, Monash University Malaysia, Malaysia.
Eur J Pharmacol. 2019 Jan 5;842:133-138. doi: 10.1016/j.ejphar.2018.10.039. Epub 2018 Oct 30.
The prevalence of stroke is high in both developing and developed nations. It causes a heavy social and financial burden to the sufferers and their caregivers. Thrombolytic therapy is the only pharmacological treatment available for stroke. However, thrombolytic agents do not provide substantial improvement on long term motor and cognitive disabilities. Thus, there is a need to explore for new compounds that can halt or reverse the deterioration of neurons in the stroke patients' brain. Polydatin, a precursor of resveratrol, is a natural stilbene commonly found in food. This review article describes how different parameters were altered with ischemic injury and polydatin treatment, why it is important and how it could be beneficial or useful in future studies. Our review of polydatin provides convincing evidence regarding the potential of polydatin to be developed into preventive or therapeutic products for ischemic stroke. Nevertheless, additional studies are necessary in order to properly elucidate the biological mechanisms of polydatin, especially its molecular mechanisms of protection and target proteins, in cerebral ischemia.
中风在发展中国家和发达国家的发病率都很高。它给患者及其护理人员带来了沉重的社会和经济负担。溶栓疗法是目前唯一可用于中风的药物治疗方法。然而，溶栓药物并不能显著改善长期的运动和认知障碍。因此，需要探索新的化合物来阻止或逆转中风患者大脑中神经元的恶化。白藜芦醇的前体——虎杖苷，是一种常见于食物中的天然二苯乙烯。这篇综述文章描述了不同参数如何随缺血性损伤和虎杖苷治疗而改变，为什么这很重要，以及它在未来的研究中如何可能是有益的。我们对虎杖苷的综述提供了令人信服的证据，表明虎杖苷有可能被开发成预防或治疗缺血性中风的产品。然而，为了正确阐明虎杖苷的生物学机制，特别是其在脑缺血中的保护作用的分子机制和靶蛋白，还需要进行更多的研究。
