Ozdemir Ozan, Aral Hale, Ruzgar Halit, Arslan Hilmi Furkan, Yigit Ozgur
Department of Otorhinolaryngology/Head and Neck Surgery, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
Department of Medical Biochemistry, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
Sisli Etfal Hastan Tip Bul. 2023 Mar 21;57(1):54-60. doi: 10.14744/SEMB.2023.38243. eCollection 2023.
The objectives of this study were to evaluate the role of oxidative stress in benign paroxysmal positional vertigo (BPPV) by measuring urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-hydroxy-guanosine (8-OHG), and 8-hydroxy-guanine levels.
Thirty-one adult female patients diagnosed with BPPV were included in this study. Patients with central pathologies and other peripheral causes of vertigo were excluded from the study. The patients were evaluated for oxidative stress during and after the BPPV attack with blood samples and spot urine tests. Depression, anxiety, and stress scale (DASS) questionnaire was used to evaluate emotional stress. A control group consisting of 30 age-matched healthy women was formed.
Urinary oxidative stress values during the attack were significantly higher than the post-treatment group and the healthy control group (p<0.05). There was no significant difference between the urinary oxidative stress values of the BPPV group after treatment and the healthy control group (p>0.05). DASS scores were significantly higher during the attack and after the treatment compared to the healthy control group (p<0.05).
The increase in spot urinary 8-OHdG, 8-OHG, and 8-hydroxy-guanine levels can be used as a biomarker for oxidative stress in patients with BPPV. Furthermore, emotional stress can also trigger BPPV attacks by increasing oxidative stress.
本研究的目的是通过测量尿8-羟基-2'-脱氧鸟苷（8-OHdG）、8-羟基鸟苷（8-OHG）和8-羟基鸟嘌呤水平，评估氧化应激在良性阵发性位置性眩晕（BPPV）中的作用。
本研究纳入了31例诊断为BPPV的成年女性患者。患有中枢性病变和其他周围性眩晕病因的患者被排除在研究之外。通过采集血样和随机尿样检测，对患者在BPPV发作期间和发作后进行氧化应激评估。使用抑郁、焦虑和压力量表（DASS）问卷评估情绪应激。组建了一个由30名年龄匹配的健康女性组成的对照组。
发作期间的尿氧化应激值显著高于治疗后组和健康对照组（p<0.05）。BPPV组治疗后的尿氧化应激值与健康对照组之间无显著差异（p>0.05）。与健康对照组相比，发作期间和治疗后的DASS评分显著更高（p<0.05）。
随机尿中8-OHdG、8-OHG和8-羟基鸟嘌呤水平的升高可作为BPPV患者氧化应激的生物标志物。此外，情绪应激也可通过增加氧化应激触发BPPV发作。
