Bundeswehr Institute of Radiobiology, Neuherbergstrasse 11, Munich 80937, Germany.
Radiat Prot Dosimetry. 2020 Jul 24;189(4):428-435. doi: 10.1093/rpd/ncaa063.
HemoDose is a software tool, which estimates absorbed doses based on blood cell counts (BCC). The aim of our study was to validate HemoDose for early dose estimates. Dose estimates generated by HemoDose were compared with dose estimates stored in SEARCH from radiation victims. Moreover, BCC from unirradiated donors and corresponding HemoDose dose estimates were analysed. We employed linear or logistic regression analysis. There was a significant correlation between calculated doses by HemoDose based on single and multiple lymphocyte counts when omitting lowest and highest dose estimates. Furthermore, there was a significant correlation between calculated doses by HemoDose based on lymphocyte counts and the estimated doses based on DIC. The dose estimates by HemoDose based on lymphocyte counts and DIC showed a comparable correlation with HARS degrees 0 and 4. In conclusion, HemoDose dose estimation based on early lymphocyte counts appears to be a promising biodosimetry tool under certain considerations.
HemoDose 是一种软件工具，它基于血细胞计数（BCC）来估计吸收剂量。我们的研究目的是验证 HemoDose 用于早期剂量估计。HemoDose 生成的剂量估计与从辐射受害者的 SEARCH 中存储的剂量估计进行了比较。此外，还分析了未受辐照供体的 BCC 及其对应的 HemoDose 剂量估计值。我们采用了线性或逻辑回归分析。在排除最低和最高剂量估计值后，基于单个和多个淋巴细胞计数的 HemoDose 计算剂量之间存在显著相关性。此外，基于淋巴细胞计数的 HemoDose 计算剂量与基于 DIC 的估计剂量之间也存在显著相关性。基于淋巴细胞计数和 DIC 的 HemoDose 剂量估计与 HARS 等级 0 和 4 具有相当的相关性。总之，基于早期淋巴细胞计数的 HemoDose 剂量估计在某些情况下似乎是一种有前途的生物剂量测定工具。
