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微生物简介:细胞发育模型生物,工业生产的得力助手。

Microbe Profile: : model organism for cellular development, and industrial workhorse.

机构信息

Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, NE2 4AX, UK.

出版信息

Microbiology (Reading). 2020 May;166(5):425-427. doi: 10.1099/mic.0.000922. Epub 2020 May 4.

DOI:10.1099/mic.0.000922
PMID:32391747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7376258/
Abstract

is the best studied model organism of the Gram-positive lineage. It is naturally transformable and has an extremely powerful genetic toolbox. It is fast growing and easy to cultivate. It is an important industrial organism, being proficient at secreting proteins and making small fine chemicals, as well as acting as a plant growth promoter. It has been an important model system for studying biofilms. Finally, it makes endospores, which have provided an exceptionally fruitful system for studying various central problems of cellular development, including the generation of asymmetry, cell fate determination and morphogenesis.

摘要

它是革兰氏阳性菌谱系中研究得最好的模式生物。它具有天然的可转化性和极其强大的遗传工具包。它生长迅速,易于培养。它是一种重要的工业生物,擅长分泌蛋白质和制造小分子精细化学品,以及作为植物生长促进剂。它一直是研究生物膜的重要模式系统。最后,它产生芽孢,这为研究细胞发育的各种核心问题提供了一个非常有成果的系统,包括不对称性的产生、细胞命运的决定和形态发生。

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本文引用的文献

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Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement.枯草芽孢杆菌,革兰氏阳性模式菌:20 年的注释完善历程。
Microb Biotechnol. 2018 Jan;11(1):3-17. doi: 10.1111/1751-7915.13043.
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Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.构建和分析枯草芽孢杆菌两个全基因组规模的缺失文库。
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