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化学合成人三叶因子 1（TFF1）及其同源二聚体为其作用机制提供了新的见解。

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

机构信息

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

出版信息

Chem Commun (Camb). 2020 Jun 14;56(47):6420-6423. doi: 10.1039/d0cc02321c. Epub 2020 May 11.

DOI:10.1039/d0cc02321c
PMID:32391824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7116170/
Abstract

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins and Helicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.

摘要

TFF1 是一种关键的胃肠道保护和修复肽。其分子作用机制尚不清楚，合成的不可操作性是公认的瓶颈。本文描述了 TFF1 及其同源二聚体的合成及其与粘蛋白和幽门螺杆菌的相互作用。TFF1 的合成方法是开发探针和治疗方法的重要里程碑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/5366cb6c03dd/EMS96565-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/3561e277ad1c/EMS96565-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/98fdce552dbc/EMS96565-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/17a84abded48/EMS96565-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/28ea828a0e47/EMS96565-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/5366cb6c03dd/EMS96565-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/3561e277ad1c/EMS96565-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/98fdce552dbc/EMS96565-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/17a84abded48/EMS96565-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/28ea828a0e47/EMS96565-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbc/7116170/5366cb6c03dd/EMS96565-f005.jpg

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The TFF Peptides xP1 and xP4 Appear in Distinctive Forms in the Gastric Mucosa: Indications for Different Protective Functions.
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