微管使大细胞保持形状。
Microtubules keep large cells in shape.
机构信息
Cell Biology, Neurobiology, and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.
出版信息
J Cell Biol. 2020 Jun 1;219(6). doi: 10.1083/jcb.202004031.
Abstract
Migrating cells need to coordinate extension and retraction of their protrusions to avoid fragmenting. Kopf et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201907154) demonstrate that microtubules help to maintain cell coherence during amoeboid migration by controlling actomyosin contractility in retracting protrusions.
摘要
迁移细胞需要协调其突起的延伸和回缩，以避免断裂。Kopf 等人（2020. J. Cell Biol. https://doi.org/10.1083/jcb.201907154）表明，微管通过控制回缩突起中的肌动球蛋白收缩力，有助于在变形虫样迁移过程中维持细胞的连贯性。
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