肌动球蛋白纤维 DApPLE 上皮顶端连接。

Actomyosin fibers DApPLE epithelial apical junctions.

机构信息

Program of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa," Consejo Superior de Investigaciones Científicas-Universidad Autóonama de Madrid, Madrid, Spain.

出版信息

J Cell Biol. 2022 May 2;221(5). doi: 10.1083/jcb.202203035. Epub 2022 Apr 20.

DOI:10.1083/jcb.202203035

PMID:35442398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9195049/

Abstract

Epithelial cell morphology is essential for cellular homeostasis, but the mechanisms by which cell shape is established remain unclear. In this study, Marivin et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111002) identify DAPLE as a linker between polarity complexes and the actomyosin network at apical junctions. By recruiting CD2P and activating Gαβγ-mediated RhoA signaling, DAPLE ensures proper cell shape and function.

摘要

上皮细胞形态对于细胞内稳态至关重要，但细胞形状形成的机制尚不清楚。在这项研究中，Marivin 等人（2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111002）发现 DAPLE 是极性复合物与顶端连接的肌动球蛋白网络之间的连接蛋白。通过招募 CD2P 并激活 Gαβγ 介导的 RhoA 信号，DAPLE 确保了细胞形状和功能的正常。