Sloan Kettering Institute and Department of Pediatrics, Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, New York.
Pediatr Blood Cancer. 2020 Jul;67(7):e28335. doi: 10.1002/pbc.28335. Epub 2020 May 11.
Oncologists and cancer biologists are frequently confronted by the question of what causes cancer? This is particularly vexing for cancers affecting children and young adults who have had limited exposure to environmental mutagens and the effects of aging. Here, I focus on a general framework of the causes of early-onset cancer development in children and young adults by relating inherited and constitutional cancer predisposition, oncogenic pathogens, and developmental mutations. This framework has implications not only for mechanistic investigation of young cancers, but should also clarify improved strategies for their treatment, screening, and potential prevention.
是什么导致了癌症？对于儿童和青年期癌症患者来说，这个问题尤其令人困扰，因为他们接触环境诱变剂和衰老影响的时间有限。在这里，我通过关联遗传性和先天性癌症易感性、致癌病原体和发育突变，重点介绍儿童和青年期癌症发病的一般原因框架。该框架不仅对年轻癌症的机制研究具有重要意义，而且还应阐明改善其治疗、筛查和潜在预防的策略。
