Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
J Infect Dis. 2020 May 11;221(Suppl 4):S370-S374. doi: 10.1093/infdis/jiaa085.
Nipah virus (NiV) outbreak occurred in Malaysia in 1998. The natural host reservoir for NiV is Pteropus bats, which are commonly found throughout Malaysia. Humans become infected when NiV spills over from the reservoir species. In this study, NiV serosurveillance in Peninsular Malaysia, particularly among the indigenous population, was performed. The collected samples were tested for presence of NiV antibodies using a comparative indirect enzyme-linked immunosorbent assay based on the recombinant NiV nucleocapsid (rNiV-N) protein. We found that 10.73% of the participants recruited in this study had antibodies against rNiV-N, suggesting possible exposure to NiV.
1998 年，马来西亚发生了尼帕病毒（NiV）疫情。尼帕病毒的自然宿主储库是果蝠，这种蝙蝠在马来西亚各地都很常见。当尼帕病毒从宿主物种溢出时，人类就会感染该病毒。在这项研究中，在马来西亚半岛进行了尼帕病毒血清学监测，特别是针对土著居民。使用基于重组尼帕病毒核衣壳（rNiV-N）蛋白的比较间接酶联免疫吸附试验来检测收集的样本中是否存在尼帕病毒抗体。我们发现，在这项研究中招募的参与者中有 10.73%的人对 rNiV-N 有抗体，这表明他们可能接触过尼帕病毒。
