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复杂脊髓脂肪瘤的外科治疗:一种新视角

Surgical Management of Complex Spinal Cord Lipomas : A New Perspective.

作者信息

Pang Dachling

机构信息

Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children, NHS Trust, London, UK.

Department of Paediatric Neurosurgery, University of California, Davis, CA, USA.

出版信息

J Korean Neurosurg Soc. 2020 May;63(3):279-313. doi: 10.3340/jkns.2020.0024. Epub 2020 May 1.

Abstract

This review summarises the classification, anatomy and embryogenesis of complex spinal cord lipomas, and describes in some detail the new technique of total lipoma resection and radical reconstruction of the affected neural placode. Its specific mission is to tackle two main issues surrounding the management of complex dysraphic lipomas : whether total resection confers better long term benefits than partial resection, and whether total resection does better than conservative treatment, i.e., no surgery, for asymptomatic lipomas. Accordingly, the 24 years progression-free survival data of the author and colleagues' series of over 350 cases of total resection are compared with historical data from multiple series (including our own) of partial resection, and total resection data specifically for asymptomatic lesions are compared with the two known series of non-surgical treatment of equivalent patients. These comparisons amply support the author's recommendation of total resection for most complex lipomas, with or without symptoms. The notable exception is the asymptomatic chaotic lipoma, whose peculiar anatomical relationship with the neural tissue defies even our aggressive surgical approach, and consequently projects worse results (admittedly of small number of cases) than for the other two lipoma subtypes of dorsal and transitional lesions. Prophylactic resection of asymptomatic chaotic lipomas is therefore not currently endorsed.

摘要

本综述总结了复杂脊髓脂肪瘤的分类、解剖结构和胚胎发生,并详细描述了脂肪瘤全切除及受累神经基板根治性重建的新技术。其具体任务是解决围绕复杂闭合性脂肪瘤治疗的两个主要问题:全切除是否比部分切除带来更好的长期益处,以及对于无症状脂肪瘤,全切除是否比保守治疗(即不手术)效果更好。因此,将作者及其同事超过350例全切除病例系列的24年无进展生存数据与多个部分切除系列(包括我们自己的)的历史数据进行比较,并将无症状病变的全切除数据与两个已知的等效患者非手术治疗系列进行比较。这些比较充分支持了作者对于大多数有症状或无症状的复杂脂肪瘤进行全切除的建议。值得注意的例外是无症状的紊乱型脂肪瘤,其与神经组织独特的解剖关系甚至使我们激进的手术方法也难以应对,因此与背侧和过渡型病变这两种其他脂肪瘤亚型相比,其预后更差(诚然病例数较少)。因此,目前不支持对无症状的紊乱型脂肪瘤进行预防性切除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23c0/7218203/ad19bf986b80/jkns-2020-0024f1.jpg

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