Department of Biochemistry, University of Allahabad, Allahabad, India.
Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel.
Arch Physiol Biochem. 2022 Oct;128(5):1156-1164. doi: 10.1080/13813455.2020.1760890. Epub 2020 May 12.
An altered lipid profile may lead to the development of CVD. We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats. Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood. Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations. Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.
脂质谱的改变可能导致 CVD 的发生。我们评估了黄芩素 (BAC) 对高脂血症大鼠脂质血症和氧化应激的保护作用。雄性 Wistar 大鼠给予高脂肪饮食 (HFD)（0.5%胆固醇、3%椰子油和 0.25%胆酸的混悬液（w/v），持续 30 天）以建立高脂血症模型。向实验大鼠补充 BAC（80mg/kg 体重）。在血液中评估氧化应激的生物标志物，包括 ROS、FRAP、GSH、PMRS、AGE、MDA、PCO、AOPP 和其他参数（对氧磷酶-1、SGOT、SGPT），包括 TNF-α和 IL-6。在 HFD 处理组中，氧化应激和炎症标志物显著增加。BAC 治疗可保护大鼠免受 HFD 介导的改变。我们的结果表明，黄芩素可提供针对 HFD 诱导的大鼠高脂血症应激和氧化还原失衡的保护。
