Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
BMC Pulm Med. 2020 May 11;20(1):135. doi: 10.1186/s12890-020-1168-0.
Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcinoma have been reported in the literature.
We report here a case of multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation. This 64-year-old woman was referred to our hospital with complaints of dizziness and vomiting. Target therapy with afatinib was initiated and the lesions in both lung and brain achieved good partial responses.
This case report revealed a phenomenon of rare intraventricular metastasis from lung cancer, which should be carefully distinguished from primary ventricular tumors. Compared to brain parenchyma metastasis, intraventricular lesions would cause more severe symptoms which may be rapidly progressive. Target therapy could become a potential option in such patients with non-drugresistant EGFR mutations.
脑是肺癌转移的最常见靶器官之一，而之前的病例中几乎没有描述过脑室癌病。迄今为止，文献中尚无肺腺癌病例报道。
我们在此报告一例肺腺癌伴 EGFR G719X 突变的多发性脑室转移病例。这名 64 岁女性因头晕和呕吐就诊。给予厄洛替尼靶向治疗，肺部和脑部的病变均获得了良好的部分缓解。
本病例报告揭示了一种罕见的肺癌脑室转移现象，需要与原发性脑室肿瘤仔细鉴别。与脑实质转移相比，脑室病变会引起更严重的症状，且可能迅速进展。对于非耐药性 EGFR 突变的此类患者，靶向治疗可能成为一种潜在选择。
