Department of Psychiatry, Amsterdam University Medical Centers (location AMC), University of Amsterdam, Meibergdreef 5, 1105 AZ, Amsterdam, Netherlands.
BMC Psychiatry. 2020 May 11;20(1):212. doi: 10.1186/s12888-020-02624-x.
Patients with psychiatric disorders, such as major depressive disorder, schizophrenia or obsessive-compulsive disorder, often suffer from cognitive dysfunction. The nature of these dysfunctions and their relation with clinical symptoms and biological parameters is not yet clear. Traditionally, cognitive dysfunction is studied in patients with specific psychiatric disorders, disregarding the fact that cognitive deficits are shared across disorders. The Across study aims to investigate cognitive functioning and its relation with psychiatric symptoms and biological parameters transdiagnostically and longitudinally.
The study recruits patients diagnosed with a variety of psychiatric disorders and has a longitudinal cohort design with an assessment at baseline and at one-year follow-up. The primary outcome measure is cognitive functioning. The secondary outcome measures include clinical symptoms, electroencephalographic, genetic and blood markers (e.g., fatty acids), and hair cortisol concentration levels.
The Across study provides an opportunity for a transdiagnostic, bottom-up, data-driven approach of investigating cognition in relation to symptoms and biological parameters longitudinally in patients with psychiatric disorders. The study may help to find new clusters of symptoms, biological markers, and cognitive dysfunctions that have better prognostic value than the current diagnostic categories. Furthermore, increased insight into the relationship among cognitive deficits, biological parameters, and psychiatric symptoms can lead to new treatment possibilities.
Netherlands Trial Register (NTR): NL8170.
患有精神障碍的患者，如重度抑郁症、精神分裂症或强迫症，通常会遭受认知功能障碍。这些功能障碍的性质及其与临床症状和生物学参数的关系尚不清楚。传统上，认知功能障碍在特定的精神障碍患者中进行研究，而忽略了认知缺陷在各种障碍中都存在的事实。跨学科研究旨在跨诊断和纵向研究认知功能及其与精神症状和生物学参数的关系。
该研究招募了被诊断为各种精神障碍的患者，并采用了纵向队列设计，在基线和一年随访时进行评估。主要结局指标是认知功能。次要结局指标包括临床症状、脑电图、遗传和血液标志物（如脂肪酸）以及头发皮质醇浓度水平。
跨学科研究提供了一个机会，可以对精神障碍患者的症状和生物学参数进行跨诊断、自下而上、数据驱动的认知研究。该研究可能有助于找到新的症状、生物标志物和认知功能障碍聚类，这些比当前的诊断类别具有更好的预后价值。此外，深入了解认知缺陷、生物学参数和精神症状之间的关系，可以为新的治疗方法提供思路。
荷兰临床试验注册中心（NTR）：NL8170。
