BCG 诱导的训练免疫：能提供针对 COVID-19 的保护吗？
BCG-induced trained immunity: can it offer protection against COVID-19?
机构信息
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, Netherlands.
出版信息
Nat Rev Immunol. 2020 Jun;20(6):335-337. doi: 10.1038/s41577-020-0337-y.
Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19.
卡介苗（BCG）接种已被报道可降低呼吸道感染的易感性，这种作用被认为是通过先天免疫机制的长期普遍增强来介导的，也称为训练性免疫。在这里，我们讨论了 BCG 对抗病毒感染的非特异性有益作用，以及这种疫苗是否可以为 COVID-19 提供保护。
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