Iversen O E, Utaaker E, Skaarland E
Department of Obstetrics & Gynecology, Haukeland Sykehus, University Hospital, Bergen, Norway.
Acta Obstet Gynecol Scand. 1988;67(6):531-7. doi: 10.3109/00016348809029865.
Prognostic factors for outcome of malignant disease should be based on objective assessments whenever possible, so that the results may be reproduced. In a prospective study, tumor samples from 75 patients were subjected to flow cytometric DNA analysis. Samples were also taken from 61 patients for estradiol and progesterone receptor measurements. The course of the disease was analysed with regard to ploidy and receptor status. Receptor status was significantly correlated with ploidy, as diploid tumors were more often receptor-positive or receptor-rich (greater than or equal to 30 fmol/mg protein). Mortality and recurrence rates were highest among patients with aneuploid or receptor-poor tumors. Ploidy, receptor status, histological grade, surgical stage, and myometrial invasion were found to be of significant prognostic value. By multivariate analysis, ploidy was indicated to be the best predictor, followed by surgical stage. DNA and receptor measurements are recommended in research on endometrial carcinoma, and may become useful in routine clinical work.
恶性疾病预后因素的评估应尽可能基于客观指标，以便结果能够重现。在一项前瞻性研究中，对75例患者的肿瘤样本进行了流式细胞术DNA分析。同时也采集了61例患者的样本进行雌二醇和孕激素受体检测。对疾病进程按照倍体和受体状态进行了分析。受体状态与倍体显著相关，因为二倍体肿瘤更常为受体阳性或富含受体（大于或等于30 fmol/mg蛋白质）。非整倍体或受体贫乏肿瘤患者的死亡率和复发率最高。倍体、受体状态、组织学分级、手术分期和肌层浸润被发现具有显著的预后价值。通过多变量分析，倍体被认为是最佳预测指标，其次是手术分期。DNA和受体检测在子宫内膜癌研究中值得推荐，并且可能在常规临床工作中发挥作用。
