Iversen O E
Am J Obstet Gynecol. 1986 Oct;155(4):770-6. doi: 10.1016/s0002-9378(86)80018-7.
In a prospective study, flow cytometric deoxyribonucleic acid analyses were performed on cell samples from benign and malignant tumors of the endometrium and benign endometrium. No ploidy aberrations were found in normal endometrium. Of 52 cases with adenocarcinomas, 38 (73%) were diploid and 14 (27%) aneuploid. Both the frequency and the degree of aneuploidy were correlated to histologic tumor grade but not to other prognostic variables such as International Federation of Gynecologists and Obstetricians stage, depth of myometrial invasion, or patient age. Patients with aneuploid tumors had a higher recurrence rate and shorter disease-free intervals as compared to those with diploid tumors. Similarly, death rates were higher and the median survival was shorter in the aneuploid group. Flow cytometric ploidy determination may therefore serve as an important prognostic parameter.
在一项前瞻性研究中，对来自子宫内膜良性和恶性肿瘤以及良性子宫内膜的细胞样本进行了流式细胞术脱氧核糖核酸分析。在正常子宫内膜中未发现倍体异常。在52例腺癌病例中，38例（73%）为二倍体，14例（27%）为非整倍体。非整倍体的频率和程度均与肿瘤组织学分级相关，但与其他预后变量无关，如国际妇产科联合会分期、肌层浸润深度或患者年龄。与二倍体肿瘤患者相比，非整倍体肿瘤患者的复发率更高，无病间期更短。同样，非整倍体组的死亡率更高，中位生存期更短。因此，流式细胞术倍体测定可能是一个重要的预后参数。
