Eriksson L, Edén S, Fröhlander N, Bengtsson B A, von Schoultz B
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
Acta Obstet Gynecol Scand. 1988;67(6):543-7. doi: 10.3109/00016348809029867.
A dramatic change in growth hormone secretion was demonstrated during the 3rd trimester of human pregnancy, when compared with the non-pregnant state. The pulsatile pattern, with intermittent high peaks, and low or undetectable levels between peaks, characteristic of normal men and non-pregnant women, was completely abolished. All the 10 pregnant women investigated had the same stable basal circulating growth hormone concentration. Values were in the range 6-10 mU/l and there was no evidence of pulsatile activity. Previously, in animal experiments, a continuous secretion of growth hormone has been shown to 'feminize' hepatic steroid metabolism, hepatic prolactin receptors, hepatic sulphatase activity and to stimulate pregnancy protein synthesis. The same biological principle could be valid also during human pregnancy and be related to maternal metabolic adjustment.
与非孕期相比，人类妊娠晚期生长激素分泌出现显著变化。正常男性和非孕期女性所特有的脉冲式分泌模式，即间歇性出现高峰值，且峰值之间水平较低或检测不到，在孕期完全消失。所研究的10名孕妇均具有相同稳定的基础循环生长激素浓度。数值范围为6 - 10 mU/l，且无脉冲式活动迹象。此前，在动物实验中，已表明生长激素的持续分泌会使肝脏类固醇代谢、肝脏催乳素受体、肝脏硫酸酯酶活性“女性化”，并刺激妊娠蛋白合成。同样的生物学原理在人类妊娠期间可能也成立，且与母体代谢调节有关。
