Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Curr Drug Deliv. 2021;18(2):147-161. doi: 10.2174/1567201817666200512104441.
Currently, despite many active compounds have been introduced to the treatment, cancer remains one of the most vital causes of mortality and reduced quality of life. Conventional cancer treatments may have undesirable consequences due to the continuous differentiating, dynamic and heterogeneous nature of cancer. Recent advances in the field of cancer treatment have promoted the development of several novel nanoformulations. Among them, the lipid coated nanosized drug delivery systems have gained an increasing attention by the researchers in this field owing to the attractive properties such as high stability and biocompatibility, prolonged circulation time, high drug loading capacity and superior efficacy. They possess the advantages of both the liposomes and polymeric nanoparticles which makes them a chosen one in the field of drug delivery and targeting. Core-shell type lipid-coated nanoparticle systems, which provide the most prominent advantages of both liposomes such as biocompatibility and polymeric/inorganic nanoparticles such as mechanic properties, offer a new approach to cancer treatment. This review discusses design and production procedures used to prepare lipid-coated nanoparticle drug delivery systems, their advantages and multifunctional role in cancer therapy and diagnosis, as well as the applications they have been used in.
目前，尽管已经引入了许多活性化合物用于治疗，但癌症仍然是导致死亡和生活质量下降的最重要原因之一。由于癌症的不断分化、动态和异质性，传统的癌症治疗方法可能会产生不良后果。近年来，癌症治疗领域的进展促进了几种新型纳米制剂的发展。其中，脂质包覆的纳米药物递送系统由于具有高稳定性和生物相容性、延长的循环时间、高载药量和优异的功效等诱人特性，引起了该领域研究人员的越来越多的关注。它们兼具脂质体和聚合物纳米粒子的优点，使其成为药物输送和靶向领域的首选。核壳型脂质包覆纳米粒子系统提供了脂质体的最显著优点，如生物相容性和聚合物/无机纳米粒子的机械性能，为癌症治疗提供了一种新方法。本文综述了制备脂质包覆纳米粒子药物递送系统的设计和生产工艺，及其在癌症治疗和诊断中的优势和多功能作用，以及它们在癌症治疗中的应用。
