Abdin Alaa Din, Suffo Shady, Alnaggar Dina, Daas Loay, Seitz Berthold
Department of Ophthalmology, Saarland University Medical Center UKS, 66421, Homburg/Saar, Germany.
Am J Ophthalmol Case Rep. 2020 Jan 7;17:100591. doi: 10.1016/j.ajoc.2020.100591. eCollection 2020 Mar.
We intend to describe an uncommon case of recurrent post-cataract fungal endophthalmitis after intravitreal injections of Bevacizumab.
A 73-year-old male, who underwent an uncomplicated cataract surgery 8 months ago, presented to our department with postoperative endophthalmitis 5 days after his fifth intravitreal injection (IVI) of bevacizumab for treatment of cystoid macula edema caused by central retinal venous occlusion 6 months ago. The visual acuity (VA) was 0.1 (20/200). The patient underwent an emergency pars plana vitrectomy. Culture of vitreous tap was negative. Eight weeks later, the patient presented again with recurrent endophthalmitis 2 days after his sixth IVI of bevacizumab. VA was hand motion. The patient was treated with an emergency anterior and posterior segment washout with intracapsular posterior intraocular lens (pIOL) extraction. Culture of pIOL revealed fungi in the capsular bag. Six months later, clinical findings were stable with no signs of intraocular inflammation, VA was 0.3 (20/60).
we assume that this is a rare case of chronic late-onset post-cataract fungal endophthalmitis, which was activated by repeated intravitreal injections of Bevacizumab.
我们旨在描述一例罕见的白内障术后真菌性眼内炎复发病例，该病例发生在玻璃体内注射贝伐单抗之后。
一名73岁男性，8个月前接受了无并发症的白内障手术，在6个月前因视网膜中央静脉阻塞导致的黄斑囊样水肿接受了第5次玻璃体内注射（IVI）贝伐单抗治疗，5天后因术后眼内炎前来我院就诊。视力（VA）为0.1（20/200）。患者接受了急诊玻璃体切割术。玻璃体穿刺液培养结果为阴性。8周后，患者在第6次玻璃体内注射贝伐单抗2天后再次出现复发性眼内炎。视力为手动。患者接受了急诊前段和后段冲洗，并进行了囊内后房型人工晶状体（pIOL）摘除术。人工晶状体培养显示囊袋内有真菌。6个月后，临床症状稳定，无眼内炎症迹象，视力为0.3（20/60）。
我们认为这是一例罕见的慢性迟发性白内障术后真菌性眼内炎病例，由反复玻璃体内注射贝伐单抗引发。
