Departamento de Química, Facultade de Ciencias and Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, 15071 A Coruña, Spain.
Chem Soc Rev. 2020 Jun 22;49(12):3834-3862. doi: 10.1039/d0cs00109k.
Synthetic supramolecular chemistry pursues not only the construction of new matter, but also control over its inherently dynamic behaviour. In this context, classic host-guest chemistry, based on the development of a myriad of macrocyclic receptors with fine-tuned affinities and selectivities, has enormously contributed to the discovery of new chemical function under self-assembly conditions. In turn, the use of molecular switches as control units within host-guest assemblies opened the door for the regulation of their dynamic interactional behaviour, which can be translated into controlled aggregation. In this review, we will focus on different strategies developed for the regulated binding of organic molecules by switchable macrocyclic hosts. As we will see, an appropriate design using stimuli-responsive versions of well-known organic receptors allows the molecular switches implemented within their structures to transform their regulated behaviour from the molecular to the supramolecular level.
超分子化学的合成不仅追求新物质的构建，还追求对其固有动态行为的控制。在这种情况下，基于开发具有精细亲和力和选择性的无数大环受体的经典主客体化学，极大地促进了在自组装条件下发现新的化学功能。反过来，将分子开关用作主体-客体组装体中的控制单元，为调节它们的动态相互作用行为打开了大门，这种行为可以转化为受控聚集。在这篇综述中，我们将重点介绍为通过可切换大环主体调节有机分子的结合而开发的不同策略。正如我们将看到的，使用众所周知的有机受体的刺激响应版本进行适当的设计，可以使结构内的分子开关将其调节行为从分子水平转换到超分子水平。
