University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille F-59000 Lille, France.
Epigenomics. 2020 Apr;12(8):715-723. doi: 10.2217/epi-2019-0290. Epub 2020 May 12.
Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining SE and their associated genes using murine functional genomics data, we highlight and discuss current limitations and open questions regarding both the sensitivity and specificity of identity genes/transcription factors predicted by SE. In this context, we point to cell/tissue-specific promoters as an important additional level of information, which we propose to combine with SE when aiming to define potential identity genes.
超增强子（SE）已成为一个热门概念，并被广泛用作定义关键身份基因的特征。在这里，我们提供了使用 SE 来定义和识别细胞/组织身份基因的观点。通过使用鼠类功能基因组学数据挖掘 SE 及其相关基因，我们强调并讨论了当前关于 SE 预测的身份基因/转录因子的敏感性和特异性的局限性和开放性问题。在这种情况下，我们指出细胞/组织特异性启动子是一个重要的额外信息层面，并建议在试图定义潜在的身份基因时将其与 SE 结合使用。
