Department of Pediatrics, People's Hospital of Deyang City, Affiliated Hospital of Chengdu Medical College, Deyang, China.
Department of Nephrology, People's Hospital of Deyang City, Affiliated Hospital of Chengdu Medical College, Deyang, China,
Int Arch Allergy Immunol. 2020;181(6):422-433. doi: 10.1159/000506807. Epub 2020 May 12.
Several studies have linked acetaminophen exposure to the risk of allergic rhinitis, with controversial results.
A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was conducted up to December 1, 2019. We included observational studies that examined the association between acetaminophen exposure and the risk of allergic rhinitis. Two reviewers independently extracted data and assessed study quality. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis.
Eighteen studies with 870,492 participants were included. Analysis showed that acetaminophen exposure was associated with an increased risk of allergic rhinitis (OR: 1.54, 95% CI: 1.41-1.69). Also, early exposure and exposure in the past year to acetaminophen was positively associated with risk of allergic rhinitis (OR: 1.34, 95% CI: 1.21-1.49 and OR: 1.74, 95% CI: 1.48-2.04, respectively). The risk of allergic rhinitis was greater for people who had acetaminophen exposure once per month over the past year (OR: 1.90, 95% CI: 1.60-2.26) compared to once per year (OR: 1.28, 95% CI: 1.11-1.48).
With our meta-analysis, we provide the evidence that exposure to acetaminophen is associated with an increased risk of allergic rhinitis. In addition, acetaminophen exposure in early life and acetaminophen exposure in the past year are positively associated with the risk of allergic rhinitis. Future research is needed to evaluate whether the association is causal.
有几项研究将对乙酰氨基酚的暴露与过敏性鼻炎的风险联系起来，但结果存在争议。
对 PubMed、Embase、Cochrane 图书馆和 Web of Science 进行了系统检索，检索截至 2019 年 12 月 1 日。我们纳入了观察性研究，这些研究调查了对乙酰氨基酚暴露与过敏性鼻炎风险之间的关系。两名评审员独立提取数据并评估研究质量。使用随机效应荟萃分析计算汇总优势比（OR）和 95%置信区间（CI）。
纳入了 18 项研究，共有 870492 名参与者。分析表明，对乙酰氨基酚暴露与过敏性鼻炎的风险增加有关（OR：1.54，95%CI：1.41-1.69）。此外，早期暴露和过去一年中对乙酰氨基酚的暴露与过敏性鼻炎的风险呈正相关（OR：1.34，95%CI：1.21-1.49 和 OR：1.74，95%CI：1.48-2.04）。与每年一次相比，过去一年中每月一次暴露于对乙酰氨基酚的人患过敏性鼻炎的风险更高（OR：1.90，95%CI：1.60-2.26）（OR：1.28，95%CI：1.11-1.48）。
通过荟萃分析，我们提供了证据表明，对乙酰氨基酚的暴露与过敏性鼻炎的风险增加有关。此外，生命早期的对乙酰氨基酚暴露和过去一年的对乙酰氨基酚暴露与过敏性鼻炎的风险呈正相关。需要进一步的研究来评估这种关联是否具有因果关系。
