Sulica V I, Kao G F
Division of Dermatology, Georgetown University Medical Center, Washington, D.C.
Am J Dermatopathol. 1988 Apr;10(2):137-41. doi: 10.1097/00000372-198804000-00007.
Squamous-cell carcinoma may arise in scars of chronic discoid lupus erythematosus. Although there have been 19 cases reported previously, detailed histopathologic features of this entity have not been recorded. We report a patient with extensive chronic discoid lupus erythematosus involving the scalp with subsequent development of multiple squamous-cell carcinomas. The tumors were locally aggressive with recurrences and invasion into the underlying skull and dura. The patient died of respiratory failure 4 1/2 years after initial surgical treatment. There was no clinical evidence of metastasis. Squamous carcinoma arising in discoid lupus erythematosus can be regarded as a low-grade carcinoma. Although about 20% of patients developed local recurrences and metastasis developed in about 30%, fatality occurred in only two patients (10.5%). Pertinent literature is reviewed, and the histopathologic findings, differential diagnosis, and biologic behavior of this tumor are discussed.
鳞状细胞癌可能发生于慢性盘状红斑狼疮的瘢痕中。尽管此前已有19例相关病例报道，但该实体的详细组织病理学特征尚未记录。我们报告1例广泛累及头皮的慢性盘状红斑狼疮患者，随后发生了多发性鳞状细胞癌。肿瘤具有局部侵袭性，出现复发并侵犯至下方颅骨和硬脑膜。患者在初次手术治疗4年半后死于呼吸衰竭。无转移的临床证据。盘状红斑狼疮中发生的鳞状细胞癌可被视为低级别癌。尽管约20%的患者出现局部复发，约30%发生转移，但仅2例患者死亡（10.5%）。本文回顾了相关文献，并讨论了该肿瘤的组织病理学表现、鉴别诊断及生物学行为。
