Spada Eva, Perego Roberta, Vitale Fabrizio, Bruno Federica, Castelli Germano, Tarantola Gaia, Baggiani Luciana, Magistrelli Sonia, Proverbio Daniela
Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milan, via dell'Università 6, 26900 Lodi, Italy.
Centro di Referenza Nazionale per le Leishmaniosi (C.Re.Na.L), Istituto Zooprofilattico Sperimentale (IZS) della Sicilia A. Mirri, Via G. Marinuzzi 3, 90129 Palermo, Italy.
Animals (Basel). 2020 May 8;10(5):817. doi: 10.3390/ani10050817.
Feline leishmaniosis (FeL) is an emerging vector-borne feline disease, with increasing numbers of cases reported and studies performed internationally. This study aimed to update the epidemiological status for FeL in stray cats in Milan, northern Italy; compare these results with previous studies in Northern Italy; and report clinicopathologic findings and coinfections in cats infected with spp. A total of 117 cats were tested for and retrovirus infection, hematological, and biochemical parameters. Demographic and clinical data were collected and FeL affected cats screened for selected coinfections. Overall, 10/117 (8.6%) cats tested positive for : in five cats DNA was found in popliteal lymph nodes and five were IFAT seropositive at titers from 1:80 to 1:160. Infected cats were concentrated in a specific area of Milan ( = 0.0154). No specific clinicopathologic abnormalities or retroviral infections were significantly linked to the infection, other than hypergammaglobulinemia ( = 0.0127). Seroreactivity to , and was found in some infected cats. A high prevalence of FeL was found in a non-endemic area of northern Italy and future studies should continually monitor this data to understand whether these cases are imported or if vectors are present in this area.
猫利什曼病（FeL）是一种新出现的媒介传播性猫病，国际上报告的病例数和开展的研究越来越多。本研究旨在更新意大利北部米兰流浪猫中FeL的流行病学状况；将这些结果与意大利北部以前的研究进行比较；并报告感染利什曼原虫属的猫的临床病理特征和合并感染情况。总共对117只猫进行了利什曼原虫和逆转录病毒感染、血液学和生化参数检测。收集了人口统计学和临床数据，并对感染FeL的猫进行了选定合并感染的筛查。总体而言，117只猫中有10只（8.6%）利什曼原虫检测呈阳性：5只猫在腘淋巴结中发现利什曼原虫DNA，5只猫间接荧光抗体试验血清学呈阳性，滴度为1:80至1:160。受感染的猫集中在米兰的一个特定区域（P = 0.0154）。除高球蛋白血症外（P = 0.0127），没有特定的临床病理异常或逆转录病毒感染与该感染有显著关联。在一些受感染的猫中发现了对杜氏利什曼原虫、婴儿利什曼原虫和墨西哥利什曼原虫的血清反应性。在意大利北部的一个非流行地区发现FeL的高流行率，未来的研究应持续监测这些数据，以了解这些病例是输入性的还是该地区存在传播媒介。
