Marquardt H, Rufino F, Weisburger J H
Science. 1977 May 27;196(4293):1000-1. doi: 10.1126/science.323974.
By the Salmonella typhimurium test, extracts of Japanese raw fish treated in the laboratory with nitrite showed mutagenic activity which is prevented by addition of ascorbate. Extracts from similarly treated beef and hot dogs were nonmutagenic. The data conform to a working concept that the high stomach cancer incidence in Japanese and certain other populations may be due to specific dietary factors of an alkylnitrosamide type.
通过鼠伤寒沙门氏菌试验，在实验室用亚硝酸盐处理过的日本生鱼提取物显示出诱变活性，而添加抗坏血酸盐可阻止这种活性。同样处理过的牛肉和热狗的提取物没有诱变作用。这些数据符合一个工作概念，即日本人和其他某些人群中胃癌高发可能归因于烷基亚硝酰胺类型的特定饮食因素。
