Department of Anatomy, Korea University College of Medicine, Brain Korea 21 plus, Seoul, 02841, Republic of Korea.
Exp Mol Med. 2020 May;52(5):730-737. doi: 10.1038/s12276-020-0434-9. Epub 2020 May 12.
Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.
线粒体功能障碍严重损害细胞健康，并常导致或影响多种疾病的进展，包括神经退行性疾病和癌症。因此，细胞必须有几种方法来监测线粒体质量的状况并维持线粒体健康。越来越多的证据表明，响应线粒体形态自发变化的分子机制与常规的线粒体质量控制系统有关。在这篇简短的综述中，我们讨论了将线粒体结构动力学与质量控制系统联系起来的最新进展。
