Kerbert Annarein J C, Jalan Rajiv
Institute for Liver and Digestive Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK.
F1000Res. 2020 Apr 29;9. doi: 10.12688/f1000research.22183.1. eCollection 2020.
Hepatic encephalopathy (HE) is a common, severe complication of advanced chronic liver disease (CLD) and has a devastating impact on the patient's quality of life and prognosis. The neurotoxin ammonia and the presence of systemic and neurological inflammation are considered the key drivers of this neuropsychiatric syndrome. Treatment options available in routine clinical practice are limited, and the development of novel therapies is hampered owing to the complexity and heterogeneity of HE. This review article aims to outline the current understanding of the pathomechanisms of HE and the recent advances in the identification and development of novel therapeutic targets.
肝性脑病（HE）是晚期慢性肝病（CLD）常见的严重并发症，对患者的生活质量和预后具有毁灭性影响。神经毒素氨以及全身和神经炎症的存在被认为是这种神经精神综合征的关键驱动因素。常规临床实践中的治疗选择有限，由于肝性脑病的复杂性和异质性，新型疗法的开发受到阻碍。这篇综述文章旨在概述目前对肝性脑病发病机制的理解以及新型治疗靶点识别与开发方面的最新进展。
