Zavvarian Mohammad-Masoud, Toossi Amirali, Khazaei Mohamad, Hong James, Fehlings Michael
Krembil Research Institute, University Health Network, Toronto, Canada.
Institute of Medical Science, University of Toronto, Toronto, Canada.
F1000Res. 2020 Apr 22;9. doi: 10.12688/f1000research.21989.1. eCollection 2020.
Spinal cord injury (SCI) leads to chronic and multifaceted disability, which severely impacts the physical and mental health as well as the socio-economic status of affected individuals. Permanent disabilities following SCI result from the failure of injured neurons to regenerate and rebuild functional connections with their original targets. Inhibitory factors present in the SCI microenvironment and the poor intrinsic regenerative capacity of adult spinal cord neurons are obstacles for regeneration and functional recovery. Considerable progress has been made in recent years in developing cell and molecular approaches to enable the regeneration of damaged spinal cord tissue. In this review, we highlight several potent cell-based approaches and genetic manipulation strategies (gene therapy) that are being investigated to reconstruct damaged or lost spinal neural circuits and explore emerging novel combinatorial approaches for enhancing recovery from SCI.
脊髓损伤（SCI）会导致慢性和多方面的残疾，严重影响患者的身心健康以及社会经济地位。SCI后的永久性残疾是由于受损神经元无法再生并与原始靶点重建功能连接所致。SCI微环境中存在的抑制因子以及成年脊髓神经元固有的再生能力差是再生和功能恢复的障碍。近年来，在开发细胞和分子方法以促进受损脊髓组织再生方面取得了相当大的进展。在这篇综述中，我们重点介绍了几种正在研究的基于细胞的有效方法和基因操作策略（基因治疗），以重建受损或丧失的脊髓神经回路，并探索用于增强SCI恢复的新兴新型组合方法。
