Endocrine and Metabolic Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, 40170 Shah Alam, Selangor, Malaysia.
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
J Obes. 2020 Apr 13;2020:3198326. doi: 10.1155/2020/3198326. eCollection 2020.
To examine the association of weight loss magnitude with changes in cardiometabolic risk markers in overweight and obese women from low socioeconomic areas engaged in a lifestyle intervention.
Analyses were performed on 243 women (mean body mass index 31.27 ± 4.14 kg/m) who completed a 12-month lifestyle intervention in low socioeconomic communities in Klang Valley, Malaysia. Analysis of covariance (ANCOVA) was used to compare changes of cardiometabolic risk factors across weight change categories (2% gain, ±2% maintain, >2 to <5% loss, and 5 to 20% loss) within intervention and control group.
A graded association for changes in waist circumference, fasting insulin, and total cholesterol (=0.002, for all variables) across the weight change categories were observed within the intervention group at six months postintervention. Participants who lost 5 to 20% of weight had the greatest improvements in those risk markers (-5.67 cm CI: -7.98 to -3.36, -4.27 U/mL CI: -7.35, -1.19, and -0.59 mmol/L CI: -.99, -0.19, respectively) compared to those who did not. Those who lost >2% to <5% weight reduced more waist circumference (-4.24 cm CI: -5.44 to -3.04) and fasting insulin (-0.36 U/mL CI: -1.95 to 1.24) than those who maintained or gained weight. No significant association was detected in changes of risk markers across the weight change categories within the control group except for waist circumference and adiponectin.
Weight loss of >2 to <5% obtained through lifestyle intervention may represent a reasonable initial weight loss target for women in the low socioeconomic community as it led to improvements in selected risk markers, particularly of diabetes risk.
探讨在参与生活方式干预的来自社会经济水平较低地区的超重和肥胖女性中，体重减轻幅度与心血管代谢风险标志物变化的相关性。
对 243 名女性（平均体重指数为 31.27±4.14kg/m²）进行了分析，这些女性在马来西亚克拉朗谷的社会经济水平较低的社区完成了为期 12 个月的生活方式干预。使用协方差分析（ANCOVA）比较了干预组和对照组内体重变化类别（增重 2%、体重保持±2%、体重减轻>2%至<5%、体重减轻 5%至 20%）中心血管代谢风险因素的变化。
在干预组中，在六个月时，体重变化类别与腰围、空腹胰岛素和总胆固醇的变化呈梯度相关性（所有变量均为 0.002）。与未减重的人相比，体重减轻 5%至 20%的人这些风险标志物的改善最大（-5.67cm CI：-7.98 至-3.36，-4.27U/mL CI：-7.35，-1.19，-0.59mmol/L CI：-0.99，-0.19）。与保持或增重的人相比，体重减轻>2%至<5%的人减少了更多的腰围（-4.24cm CI：-5.44 至-3.04）和空腹胰岛素（-0.36U/mL CI：-1.95 至 1.24）。除了腰围和脂联素外，对照组中体重变化类别与风险标志物变化之间未发现显著相关性。
通过生活方式干预获得的>2%至<5%的体重减轻可能是社会经济水平较低社区女性的一个合理的初始体重减轻目标，因为它改善了一些风险标志物，特别是糖尿病风险。
