Swift Damon L, Johannsen Neil M, Lavie Carl J, Earnest Conrad P, Blair Steven N, Church Timothy S
Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Center for Health Disparities, East Carolina University, Greenville, North Carolina, USA.
Obesity (Silver Spring). 2016 Apr;24(4):812-9. doi: 10.1002/oby.21404. Epub 2016 Mar 3.
To determine response rates for clinically significant weight loss (CWL) following different aerobic exercise training amounts and whether enhanced cardiometabolic adaptations are observed with CWL compared to modest weight loss (MWL) or neither.
Participants (N = 330) performed 6 months of aerobic training at 4 kcal per kilogram per week (KKW), 8 KKW, or 12 KKW (50%, 100%, and 150% of recommended levels respectively). Weight loss was categorized as CWL (≥5%) or MWL (3.0% to 4.9%) or neither.
The CWL response rate was greater in the 8 KKW group (20.2%, CI: 13.0% to 27.5%) compared to 4 KKW (10.3%, CI: 4.6% to 16.0%), but not compared to the 12 KKW group (14.6%, CI: 7.6% to 21.6%). Reductions in HOMA-IR were observed in participants with CWL (-0.60, CI: -0.98 to -0.22) and with MWL (-0.48, CI: -0.87 to -0.10), but not those who achieved neither (-0.06, CI -0.22 to 0.10). No changes between groups were observed for cholesterol, fitness, or blood pressure.
Low response rates for CWL were observed following training, even at levels above recommended levels. Achieving MWL with exercise may represent a reasonable initial weight loss target since the improvement in insulin resistance with MWL is similar to what is achieved with CWL.
确定不同有氧运动训练量后临床上显著体重减轻（CWL）的反应率，以及与适度体重减轻（MWL）或无体重减轻相比，CWL是否能观察到增强的心脏代谢适应性。
参与者（N = 330）进行为期6个月的有氧运动训练，训练强度分别为每周每千克4千卡（KKW）、8 KKW或12 KKW（分别为推荐水平的50%、100%和150%）。体重减轻分为CWL（≥5%）或MWL（3.0%至4.9%）或无体重减轻。
与4 KKW组（10.3%，CI：4.6%至16.0%）相比，8 KKW组的CWL反应率更高（20.2%，CI：13.0%至27.5%），但与12 KKW组（14.6%，CI：7.6%至21.6%）相比无差异。CWL参与者（-0.60，CI：-0.98至-0.22）和MWL参与者（-0.48，CI：-0.87至-0.10）的胰岛素抵抗稳态模型评估（HOMA-IR）降低，但无体重减轻者未降低（-0.06，CI -0.22至0.10）。各组之间的胆固醇、体能或血压无变化。
训练后CWL的反应率较低，即使训练量高于推荐水平。通过运动实现MWL可能是一个合理的初始体重减轻目标，因为MWL导致的胰岛素抵抗改善与CWL相似。
