Babar Arslan, Lak Hassan, Chawla Sanchit, Mahalwar Gauranga, Maroo Anjli
Internal Medicine, Cleveland Clinic - Fairview Hospital, Cleveland, USA.
Internal Medicine, Cleveland Clinic Akron General, Akron, USA.
Cureus. 2020 Apr 11;12(4):e7634. doi: 10.7759/cureus.7634.
Melanoma is a highly aggressive disease with the risk of developing metastasis to virtually all organs including the heart, which can manifest as arrhythmia, right ventricular obstruction, heart failure, or pericardial effusion. Only a few reports are found in the literature of metastatic melanoma, causing ventricular arrhythmia. Prior to the advent of contemporary therapies, cardiac metastases implied a very poor prognosis. The use of immune checkpoint inhibitors and targeted therapy has greatly improved survival outcomes of metastatic melanoma. Aggressive therapy of cardiac metastasis including cardiac surgery can yield good outcomes. We present a case of a 57-year old gentleman with metastatic melanoma and cardiac involvement who initially presented as a ventricular arrhythmia and was successfully treated with immune checkpoint inhibitors and targeted therapy.
黑色素瘤是一种侵袭性很强的疾病，几乎有转移至包括心脏在内的所有器官的风险，心脏转移可表现为心律失常、右心室梗阻、心力衰竭或心包积液。文献中仅有少数关于转移性黑色素瘤导致室性心律失常的报道。在当代疗法出现之前，心脏转移意味着预后极差。免疫检查点抑制剂和靶向治疗的应用极大地改善了转移性黑色素瘤的生存结局。包括心脏手术在内的积极的心脏转移治疗可产生良好的效果。我们报告一例57岁男性转移性黑色素瘤合并心脏受累患者，该患者最初表现为室性心律失常，经免疫检查点抑制剂和靶向治疗成功治愈。
